The Wnt signaling pathway: prospects for pharmacological regulation
Wnt cascade is one of the most important signal pathways in the cell, which is required for normal embryonic development, differentiation, maintenance of stem cell phenotype and migration. Mutations in this pathway are associated with tumor growth (especially with colon cancers, hepatocarcinomas and...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2016-04-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/52 |
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| _version_ | 1850024998992871424 |
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| author | V. V. Tatarskiy |
| author_facet | V. V. Tatarskiy |
| author_sort | V. V. Tatarskiy |
| collection | DOAJ |
| description | Wnt cascade is one of the most important signal pathways in the cell, which is required for normal embryonic development, differentiation, maintenance of stem cell phenotype and migration. Mutations in this pathway are associated with tumor growth (especially with colon cancers, hepatocarcinomas and leukemias), where they participate in maintenance of tumor-initiating cells and metastasing. Because of that there is a considerable interest to develop inhibitors of Wnt pathway as anti-tumor agent. But this inhibitors are still only in early stages of clinical investigations. In this article we review the main targets for this anti-cancer agents and their preclinical and clinical status. |
| format | Article |
| id | doaj-art-da4b4434be8940d2960eeb88c9b405f6 |
| institution | DOAJ |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2016-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-da4b4434be8940d2960eeb88c9b405f62025-08-20T03:00:58ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872016-04-0131283110.17650/2313-805X.2016.3.1.28-3151The Wnt signaling pathway: prospects for pharmacological regulationV. V. Tatarskiy0Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaWnt cascade is one of the most important signal pathways in the cell, which is required for normal embryonic development, differentiation, maintenance of stem cell phenotype and migration. Mutations in this pathway are associated with tumor growth (especially with colon cancers, hepatocarcinomas and leukemias), where they participate in maintenance of tumor-initiating cells and metastasing. Because of that there is a considerable interest to develop inhibitors of Wnt pathway as anti-tumor agent. But this inhibitors are still only in early stages of clinical investigations. In this article we review the main targets for this anti-cancer agents and their preclinical and clinical status.https://umo.abvpress.ru/jour/article/view/52wntβ-catenintumor-initiating cellsmetastasis |
| spellingShingle | V. V. Tatarskiy The Wnt signaling pathway: prospects for pharmacological regulation Успехи молекулярной онкологии wnt β-catenin tumor-initiating cells metastasis |
| title | The Wnt signaling pathway: prospects for pharmacological regulation |
| title_full | The Wnt signaling pathway: prospects for pharmacological regulation |
| title_fullStr | The Wnt signaling pathway: prospects for pharmacological regulation |
| title_full_unstemmed | The Wnt signaling pathway: prospects for pharmacological regulation |
| title_short | The Wnt signaling pathway: prospects for pharmacological regulation |
| title_sort | wnt signaling pathway prospects for pharmacological regulation |
| topic | wnt β-catenin tumor-initiating cells metastasis |
| url | https://umo.abvpress.ru/jour/article/view/52 |
| work_keys_str_mv | AT vvtatarskiy thewntsignalingpathwayprospectsforpharmacologicalregulation AT vvtatarskiy wntsignalingpathwayprospectsforpharmacologicalregulation |