The role of IGF2BP3/SPOP/c-Myc loop in paclitaxel resistance of endometrial cancer

The role of IGF2BP3/SPOP/c-Myc loop in paclitaxel resistance of endometrial cancer

Abstract Paclitaxel combination therapy is the main chemotherapy regimen for endometrial cancer (EC); however, subsequent drug resistance is a bottleneck limiting its widespread clinical application. We found that human insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) was abnormally ele...

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Main Authors: Yidong Ge, Lili Kong, Yuxuan Li, Zongdong Yu, Fengguang Zhai, Ziqing Zhan, Gun Chen, Shuyan Wang, Haoyun Wang, Yuxuan Wang, Jianan Zhao, Lechen Hu, Jianing Mao, Siyuan Wang, Jiaxin Shi, Mengxiang Zhao, Pengrong Lou, Meng Ye, Xiaofeng Jin
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08065-0
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