Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy
IntroductionChronic injury to the rectus femoris muscle induces and exacerbates the progression of knee osteoarthritis (KOA). However, the lesion characteristics of the rectus femoris muscle in KOA at different stages have not been fully characterized. The aim of this study was to analyze the patter...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1496425/full |
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| author | Wen-Ying Yu Wen-Ying Yu Jing Liu Jing Liu Ze-Hao Lin Ze-Hao Lin Hong Liu Hong Liu Liang-Zhi Zhang Liang-Zhi Zhang Xiang-Long Feng Xiang-Long Feng Zhong-Biao Xiu Zhong-Biao Xiu Zhong-Biao Xiu |
| author_facet | Wen-Ying Yu Wen-Ying Yu Jing Liu Jing Liu Ze-Hao Lin Ze-Hao Lin Hong Liu Hong Liu Liang-Zhi Zhang Liang-Zhi Zhang Xiang-Long Feng Xiang-Long Feng Zhong-Biao Xiu Zhong-Biao Xiu Zhong-Biao Xiu |
| author_sort | Wen-Ying Yu |
| collection | DOAJ |
| description | IntroductionChronic injury to the rectus femoris muscle induces and exacerbates the progression of knee osteoarthritis (KOA). However, the lesion characteristics of the rectus femoris muscle in KOA at different stages have not been fully characterized. The aim of this study was to analyze the pattern of lesion characteristics of the rectus femoris muscle at different stages of KOA and to investigate the mechanism by which ultrasound-guided acupotomy operations can prevent and control KOA.MethodsEarly, middle, and late-stage rabbit KOA models were constructed using the modified Videman method. Ultrasonography was used to record the elastic modulus and cross-sectional area of the rectus femoris muscle, and morphology was used to observe the ultramicroscopic changes in the rectus femoris muscle and assess the degree of fibrosis. Additionally, ultrasound-guided acupotomy operations were performed on the rabbit model of late-stage KOA, and alterations in the key molecular markers of rectus femoris fibrosis were determined using Western Blot and qPCR methods.ResultsAs the disease progressed, the elastic modulus of the rectus femoris muscle in KOA rabbits gradually increased, the cross-sectional area gradually decreased, and the degree of fibrosis increased. In contrast, the degree of fibrosis in the rectus femoris muscle improved after ultrasound-guided acupotomy intervention.ConclusionThese findings highlight the gradual increase in the modulus of elasticity, the gradual decrease in cross-sectional area, and the increased fibrosis of the rectus femoris muscle in KOA rabbits as the disease progressed. Ultrasoundguided acupotomy operations have been shown to have a protective effect on KOA cartilage and to delay the progression of KOA by ameliorating pathological changes in the rectus femoris muscle. The mechanism may involve reducing chronic injury to the rectus femoris muscle and protecting joint homeostasis by attenuating the degree of rectus femoris fibrosis. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-da334c2d662e42988a519d58f5c2a5e52025-01-23T11:32:04ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-01-011510.3389/fphys.2024.14964251496425Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomyWen-Ying Yu0Wen-Ying Yu1Jing Liu2Jing Liu3Ze-Hao Lin4Ze-Hao Lin5Hong Liu6Hong Liu7Liang-Zhi Zhang8Liang-Zhi Zhang9Xiang-Long Feng10Xiang-Long Feng11Zhong-Biao Xiu12Zhong-Biao Xiu13Zhong-Biao Xiu14Department of Orthopaedics and Traumatology, The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFirst Clinical Medical College, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaDepartment of Pain, The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFujian Clinical Research Center for Chronic Musculoskeletal Diseases via Integrative Medicine, Fuzhou, ChinaDepartment of Orthopaedics and Traumatology, The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFirst Clinical Medical College, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaDepartment of Orthopaedics and Traumatology, The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFujian Clinical Research Center for Chronic Musculoskeletal Diseases via Integrative Medicine, Fuzhou, ChinaDepartment of Orthopaedics and Traumatology, The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFujian Clinical Research Center for Chronic Musculoskeletal Diseases via Integrative Medicine, Fuzhou, ChinaDepartment of Orthopaedics and Traumatology, The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFirst Clinical Medical College, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaDepartment of Orthopaedics and Traumatology, The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFujian Clinical Research Center for Chronic Musculoskeletal Diseases via Integrative Medicine, Fuzhou, ChinaKey Laboratory of Orthopaedic Injury and Sports Rehabilitation, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaIntroductionChronic injury to the rectus femoris muscle induces and exacerbates the progression of knee osteoarthritis (KOA). However, the lesion characteristics of the rectus femoris muscle in KOA at different stages have not been fully characterized. The aim of this study was to analyze the pattern of lesion characteristics of the rectus femoris muscle at different stages of KOA and to investigate the mechanism by which ultrasound-guided acupotomy operations can prevent and control KOA.MethodsEarly, middle, and late-stage rabbit KOA models were constructed using the modified Videman method. Ultrasonography was used to record the elastic modulus and cross-sectional area of the rectus femoris muscle, and morphology was used to observe the ultramicroscopic changes in the rectus femoris muscle and assess the degree of fibrosis. Additionally, ultrasound-guided acupotomy operations were performed on the rabbit model of late-stage KOA, and alterations in the key molecular markers of rectus femoris fibrosis were determined using Western Blot and qPCR methods.ResultsAs the disease progressed, the elastic modulus of the rectus femoris muscle in KOA rabbits gradually increased, the cross-sectional area gradually decreased, and the degree of fibrosis increased. In contrast, the degree of fibrosis in the rectus femoris muscle improved after ultrasound-guided acupotomy intervention.ConclusionThese findings highlight the gradual increase in the modulus of elasticity, the gradual decrease in cross-sectional area, and the increased fibrosis of the rectus femoris muscle in KOA rabbits as the disease progressed. Ultrasoundguided acupotomy operations have been shown to have a protective effect on KOA cartilage and to delay the progression of KOA by ameliorating pathological changes in the rectus femoris muscle. The mechanism may involve reducing chronic injury to the rectus femoris muscle and protecting joint homeostasis by attenuating the degree of rectus femoris fibrosis.https://www.frontiersin.org/articles/10.3389/fphys.2024.1496425/fullevolutionary patternfibrosisosteoarthritisrectus femorisultrasound-guided acupotomy |
| spellingShingle | Wen-Ying Yu Wen-Ying Yu Jing Liu Jing Liu Ze-Hao Lin Ze-Hao Lin Hong Liu Hong Liu Liang-Zhi Zhang Liang-Zhi Zhang Xiang-Long Feng Xiang-Long Feng Zhong-Biao Xiu Zhong-Biao Xiu Zhong-Biao Xiu Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy Frontiers in Physiology evolutionary pattern fibrosis osteoarthritis rectus femoris ultrasound-guided acupotomy |
| title | Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy |
| title_full | Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy |
| title_fullStr | Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy |
| title_full_unstemmed | Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy |
| title_short | Characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound-guided acupotomy |
| title_sort | characterization of rectus femoris lesions in knee osteoarthritis at different stages and the effect of ultrasound guided acupotomy |
| topic | evolutionary pattern fibrosis osteoarthritis rectus femoris ultrasound-guided acupotomy |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1496425/full |
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