Role and sensitivity of Positron Emission Tomography with [18F]Fluorodeoxyglucose in diagnosis and follow-up of patients affected by chronic pulmonary aspergillosis (CPA)
Introduction: PET/CT is considered as a powerful tool to diagnose, stage, and monitor patients with a variety of diseases. In this study, we assessed the sensitivity and the degree of agreement between 18F-FDG PET/CT and serological tests in diagnosis and follow-up of patients affected by chronic pu...
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Edizioni FS
2018-03-01
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| Series: | Journal of Health and Social Sciences |
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| Online Access: | http://journalhss.com/wp-content/uploads/jhss31_49-58.pdf |
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| author | Gianfranco Schiraldi Cristina Elena Popescu Michele Chiericozzi Salvatore Lo Cicero Flavio Allegri Franco Mosca Claudio Rossetti |
| author_facet | Gianfranco Schiraldi Cristina Elena Popescu Michele Chiericozzi Salvatore Lo Cicero Flavio Allegri Franco Mosca Claudio Rossetti |
| author_sort | Gianfranco Schiraldi |
| collection | DOAJ |
| description | Introduction: PET/CT is considered as a powerful tool to diagnose, stage, and monitor patients with a variety of diseases. In this study, we assessed the sensitivity and the degree of agreement between 18F-FDG PET/CT and serological tests in diagnosis and follow-up of patients affected by chronic pulmonary
aspergillosis (CPA).
Methods: Thirty-seven adult patients (21 males and 16 females) affected by CPA were recruited during the study period (2010 - 2017). At the time of first diagnosis, we compared sensitivity of 18F-FDG PET/CT and serologic tests (i.e., identification of Aspergillus-specific IgE and IgG antibodies using IFA and
ELISA). 12 months after the treatment, we repeated tests only in patients with possible active disease to make a comparison between serological tests and 18F-FDG PET/CT. Sensitivity was calculated as the proportion of positive results obtained with the index test among cases. The agreement between diagnostic
techniques was assessed using the Kappa coefficient. The level of significance was set at 5% (P < 0.05).
Results: At the time of first diagnosis, agreement between 18F-FDG PET/CT and serologic tests was ‘almost perfect’ (88%, Kappa = 0.846, P < 0.05), whereas it was ‘good’ at 12 months follow-up (81%, Kappa = 0.684, P < 0.05). At first diagnosis, serological test had a higher sensitivity (94.59%, 95% Confidence
Interval [CI] 81.81% to 99.34%) in comparison with 18F-FDG PET/CT (83.78%, 95% CI 67.99% to 93.81%). Conversely, at 12-month follow-up, 18F-FDG PET/CT showed higher sensitivity (93.75, 95% CI 69.77% to 99.84%) than serological test group (75%, 95% CI 47.62% to 92.73%).
Discussion and Conclusion: Our findings demonstrate that both methods are suitable and have almost equivalent sensitivity in diagnosis and follow-up of patients affected by CPA with active disease. 18F-FDG PET/CT scan is a reliable support tool for clinical and serological data in the diagnosis and follow-up of
aspergillosis infection, providing additional information on metabolic activity, accurate anatomic localization and extent of disease. |
| format | Article |
| id | doaj-art-da32af4084514706a1c70e32fe5100d6 |
| institution | Kabale University |
| issn | 2499-2240 2499-5886 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | Edizioni FS |
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| series | Journal of Health and Social Sciences |
| spelling | doaj-art-da32af4084514706a1c70e32fe5100d62025-01-18T18:20:30ZengEdizioni FSJournal of Health and Social Sciences2499-22402499-58862018-03-0131495810.19204/2018/rlnd5Role and sensitivity of Positron Emission Tomography with [18F]Fluorodeoxyglucose in diagnosis and follow-up of patients affected by chronic pulmonary aspergillosis (CPA)Gianfranco Schiraldi0Cristina Elena Popescu1Michele Chiericozzi2Salvatore Lo Cicero3Flavio Allegri4Franco Mosca5Claudio Rossetti6 Department of Pneumology, IRCCS Auxologico, Milan, Italy Department of Nuclear Medicine, Niguarda Cà Granda Hospital, Milan, ItalyDepartment of Pneumology, Niguarda Cà Granda Hospital, Milan, Italy Department of Pneumology, Niguarda Cà Granda Hospital, Milan, ItalyDepartment of Pneumology, National Cancer Center, Milan, ItalyHealth Service Department, State Police, Ministry of Interior, Rome, ItalyDepartment of Nuclear Medicine, Niguarda Cà Granda Hospital, Milan, ItalyIntroduction: PET/CT is considered as a powerful tool to diagnose, stage, and monitor patients with a variety of diseases. In this study, we assessed the sensitivity and the degree of agreement between 18F-FDG PET/CT and serological tests in diagnosis and follow-up of patients affected by chronic pulmonary aspergillosis (CPA). Methods: Thirty-seven adult patients (21 males and 16 females) affected by CPA were recruited during the study period (2010 - 2017). At the time of first diagnosis, we compared sensitivity of 18F-FDG PET/CT and serologic tests (i.e., identification of Aspergillus-specific IgE and IgG antibodies using IFA and ELISA). 12 months after the treatment, we repeated tests only in patients with possible active disease to make a comparison between serological tests and 18F-FDG PET/CT. Sensitivity was calculated as the proportion of positive results obtained with the index test among cases. The agreement between diagnostic techniques was assessed using the Kappa coefficient. The level of significance was set at 5% (P < 0.05). Results: At the time of first diagnosis, agreement between 18F-FDG PET/CT and serologic tests was ‘almost perfect’ (88%, Kappa = 0.846, P < 0.05), whereas it was ‘good’ at 12 months follow-up (81%, Kappa = 0.684, P < 0.05). At first diagnosis, serological test had a higher sensitivity (94.59%, 95% Confidence Interval [CI] 81.81% to 99.34%) in comparison with 18F-FDG PET/CT (83.78%, 95% CI 67.99% to 93.81%). Conversely, at 12-month follow-up, 18F-FDG PET/CT showed higher sensitivity (93.75, 95% CI 69.77% to 99.84%) than serological test group (75%, 95% CI 47.62% to 92.73%). Discussion and Conclusion: Our findings demonstrate that both methods are suitable and have almost equivalent sensitivity in diagnosis and follow-up of patients affected by CPA with active disease. 18F-FDG PET/CT scan is a reliable support tool for clinical and serological data in the diagnosis and follow-up of aspergillosis infection, providing additional information on metabolic activity, accurate anatomic localization and extent of disease.http://journalhss.com/wp-content/uploads/jhss31_49-58.pdfDiagnosis pulmonary aspergillosisPositron Emission Tomographysensitivityserological test |
| spellingShingle | Gianfranco Schiraldi Cristina Elena Popescu Michele Chiericozzi Salvatore Lo Cicero Flavio Allegri Franco Mosca Claudio Rossetti Role and sensitivity of Positron Emission Tomography with [18F]Fluorodeoxyglucose in diagnosis and follow-up of patients affected by chronic pulmonary aspergillosis (CPA) Journal of Health and Social Sciences Diagnosis pulmonary aspergillosis Positron Emission Tomography sensitivity serological test |
| title | Role and sensitivity of Positron Emission Tomography with [18F]Fluorodeoxyglucose in diagnosis and follow-up of patients affected by chronic pulmonary aspergillosis (CPA) |
| title_full | Role and sensitivity of Positron Emission Tomography with [18F]Fluorodeoxyglucose in diagnosis and follow-up of patients affected by chronic pulmonary aspergillosis (CPA) |
| title_fullStr | Role and sensitivity of Positron Emission Tomography with [18F]Fluorodeoxyglucose in diagnosis and follow-up of patients affected by chronic pulmonary aspergillosis (CPA) |
| title_full_unstemmed | Role and sensitivity of Positron Emission Tomography with [18F]Fluorodeoxyglucose in diagnosis and follow-up of patients affected by chronic pulmonary aspergillosis (CPA) |
| title_short | Role and sensitivity of Positron Emission Tomography with [18F]Fluorodeoxyglucose in diagnosis and follow-up of patients affected by chronic pulmonary aspergillosis (CPA) |
| title_sort | role and sensitivity of positron emission tomography with 18f fluorodeoxyglucose in diagnosis and follow up of patients affected by chronic pulmonary aspergillosis cpa |
| topic | Diagnosis pulmonary aspergillosis Positron Emission Tomography sensitivity serological test |
| url | http://journalhss.com/wp-content/uploads/jhss31_49-58.pdf |
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