Clinical Aspects of Trace Elements: Zinc in Human Nutrition - Assessment of Zinc Status
Because the limiting and vulnerable zinc pool has not been identified, it becomes a challenge to determine which of the many zinc pools is most susceptible to deficiency. As a consequence, defining and assessing zinc status in the individual patient is a somewhat uncertain process. Laboratory analys...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
1996-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1996/412043 |
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| _version_ | 1832551983249096704 |
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| author | Michelle M Pluhator Alan Br Thomson Richard N Fedorak |
| author_facet | Michelle M Pluhator Alan Br Thomson Richard N Fedorak |
| author_sort | Michelle M Pluhator |
| collection | DOAJ |
| description | Because the limiting and vulnerable zinc pool has not been identified, it becomes a challenge to determine which of the many zinc pools is most susceptible to deficiency. As a consequence, defining and assessing zinc status in the individual patient is a somewhat uncertain process. Laboratory analysis of zinc status is difficult because no single biochemical criterion can reliably reflect zinc body stores. Many indexes have been examined in the hopes of discovering a method for the assessment of zinc nutriture. None of the methods currently used can be wholeheartedly recommended because they are fraught with problems that affect their use and interpretation. However, these methods remain in use for clinical and research purposes, though their benefits and drawbacks must always be acknowledged. Until an acceptable method of analysis is discovered, clinicians must rely for confirmation of zinc deficiency on a process of supplementing with zinc and observing the patient’s response. The main indexes (plasma/serum, erythrocyte, leukocyte, neutrophil, urine, hair and salivary zinc levels, taste acuity and oral zinc tolerance tests, and measurement of metallothionein levels) are reviewed. Measurement of plasma or erythrocyte metallothionein levels shows promise as a future tool for the accurate determination of zinc status. |
| format | Article |
| id | doaj-art-da2bfc6e141e4e6b8bcef2c369fd2139 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1996-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-da2bfc6e141e4e6b8bcef2c369fd21392025-02-03T06:00:02ZengWileyCanadian Journal of Gastroenterology0835-79001996-01-01101374210.1155/1996/412043Clinical Aspects of Trace Elements: Zinc in Human Nutrition - Assessment of Zinc StatusMichelle M Pluhator0Alan Br Thomson1Richard N Fedorak2Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, CanadaDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, CanadaDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, CanadaBecause the limiting and vulnerable zinc pool has not been identified, it becomes a challenge to determine which of the many zinc pools is most susceptible to deficiency. As a consequence, defining and assessing zinc status in the individual patient is a somewhat uncertain process. Laboratory analysis of zinc status is difficult because no single biochemical criterion can reliably reflect zinc body stores. Many indexes have been examined in the hopes of discovering a method for the assessment of zinc nutriture. None of the methods currently used can be wholeheartedly recommended because they are fraught with problems that affect their use and interpretation. However, these methods remain in use for clinical and research purposes, though their benefits and drawbacks must always be acknowledged. Until an acceptable method of analysis is discovered, clinicians must rely for confirmation of zinc deficiency on a process of supplementing with zinc and observing the patient’s response. The main indexes (plasma/serum, erythrocyte, leukocyte, neutrophil, urine, hair and salivary zinc levels, taste acuity and oral zinc tolerance tests, and measurement of metallothionein levels) are reviewed. Measurement of plasma or erythrocyte metallothionein levels shows promise as a future tool for the accurate determination of zinc status.http://dx.doi.org/10.1155/1996/412043 |
| spellingShingle | Michelle M Pluhator Alan Br Thomson Richard N Fedorak Clinical Aspects of Trace Elements: Zinc in Human Nutrition - Assessment of Zinc Status Canadian Journal of Gastroenterology |
| title | Clinical Aspects of Trace Elements: Zinc in Human Nutrition - Assessment of Zinc Status |
| title_full | Clinical Aspects of Trace Elements: Zinc in Human Nutrition - Assessment of Zinc Status |
| title_fullStr | Clinical Aspects of Trace Elements: Zinc in Human Nutrition - Assessment of Zinc Status |
| title_full_unstemmed | Clinical Aspects of Trace Elements: Zinc in Human Nutrition - Assessment of Zinc Status |
| title_short | Clinical Aspects of Trace Elements: Zinc in Human Nutrition - Assessment of Zinc Status |
| title_sort | clinical aspects of trace elements zinc in human nutrition assessment of zinc status |
| url | http://dx.doi.org/10.1155/1996/412043 |
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