Long-term Follow-up of Patients Undergoing Nephrectomy for Urolithiasis
ABSTRACT Purpose: This prospective study aimed to identify risk factors associated with progression to stage 3 chronic kidney disease (CKD) and the occurrence of kidney stone formation or growth following nephrectomy for urolithiasis. Materials and methods: From January 2006 to May 2013, patients...
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| Format: | Article |
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Sociedade Brasileira de Urologia
2025-01-01
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| Series: | International Brazilian Journal of Urology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382025000100402&lng=en&tlng=en |
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| author | Thiago Augusto Cunha Ferreira Alexandre Danilovic Samirah Abreu Gomes Fabio Carvalho Vicentini Giovanni Scala Marchini Fábio César Miranda Torricelli Carlos Alfredo Batagello William Carlos Nahas Eduardo Mazzucchi |
| author_facet | Thiago Augusto Cunha Ferreira Alexandre Danilovic Samirah Abreu Gomes Fabio Carvalho Vicentini Giovanni Scala Marchini Fábio César Miranda Torricelli Carlos Alfredo Batagello William Carlos Nahas Eduardo Mazzucchi |
| author_sort | Thiago Augusto Cunha Ferreira |
| collection | DOAJ |
| description | ABSTRACT Purpose: This prospective study aimed to identify risk factors associated with progression to stage 3 chronic kidney disease (CKD) and the occurrence of kidney stone formation or growth following nephrectomy for urolithiasis. Materials and methods: From January 2006 to May 2013, patients undergoing nephrectomy for urolithiasis were enrolled. Renal function was assessed using estimated glomerular filtration rate (eGFR) via the Chronic Kidney Disease Epidemiology Collaboration equation, while kidney stone events were detected using computed tomography. Results: Among 107 patients followed for an average of 83.5 months, type 2 diabetes mellitus (T2DM) significantly increased the risk of progression to stage 3 CKD by 34.79-fold (p=0.004). Age was associated with a 15% increase in the odds of developing stage 3 CKD per year (p=0.01), while higher preoperative eGFR was protective (OR=0.84, p<0.01). DMSA-99mTc values below 15% were less likely to lead to renal function deterioration. New kidney stone formation occurred in 15.9% of patients and stone growth observed in 12.1%. Contralateral kidney stones (p<0.01) and hypercalciuria (p=0.03) were identified as risk factors for kidney stone events. Conclusions: T2DM and age were predictors of CKD progression, while higher preoperative eGFR was protective. Hypercalciuria and contralateral kidney stones increased the risk of kidney stone formation and/or growth post-nephrectomy for urolithiasis. |
| format | Article |
| id | doaj-art-da1f028425b241c8baebfd2fafb8386d |
| institution | Kabale University |
| issn | 1677-6119 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj-art-da1f028425b241c8baebfd2fafb8386d2025-02-04T07:36:11ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192025-01-0151110.1590/s1677-5538.ibju.2024.0375Long-term Follow-up of Patients Undergoing Nephrectomy for UrolithiasisThiago Augusto Cunha FerreiraAlexandre DanilovicSamirah Abreu GomesFabio Carvalho Vicentinihttps://orcid.org/0000-0003-3745-341XGiovanni Scala MarchiniFábio César Miranda TorricelliCarlos Alfredo BatagelloWilliam Carlos NahasEduardo MazzucchiABSTRACT Purpose: This prospective study aimed to identify risk factors associated with progression to stage 3 chronic kidney disease (CKD) and the occurrence of kidney stone formation or growth following nephrectomy for urolithiasis. Materials and methods: From January 2006 to May 2013, patients undergoing nephrectomy for urolithiasis were enrolled. Renal function was assessed using estimated glomerular filtration rate (eGFR) via the Chronic Kidney Disease Epidemiology Collaboration equation, while kidney stone events were detected using computed tomography. Results: Among 107 patients followed for an average of 83.5 months, type 2 diabetes mellitus (T2DM) significantly increased the risk of progression to stage 3 CKD by 34.79-fold (p=0.004). Age was associated with a 15% increase in the odds of developing stage 3 CKD per year (p=0.01), while higher preoperative eGFR was protective (OR=0.84, p<0.01). DMSA-99mTc values below 15% were less likely to lead to renal function deterioration. New kidney stone formation occurred in 15.9% of patients and stone growth observed in 12.1%. Contralateral kidney stones (p<0.01) and hypercalciuria (p=0.03) were identified as risk factors for kidney stone events. Conclusions: T2DM and age were predictors of CKD progression, while higher preoperative eGFR was protective. Hypercalciuria and contralateral kidney stones increased the risk of kidney stone formation and/or growth post-nephrectomy for urolithiasis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382025000100402&lng=en&tlng=enUrolithiasisNephrectomyGlomerular Filtration Rate |
| spellingShingle | Thiago Augusto Cunha Ferreira Alexandre Danilovic Samirah Abreu Gomes Fabio Carvalho Vicentini Giovanni Scala Marchini Fábio César Miranda Torricelli Carlos Alfredo Batagello William Carlos Nahas Eduardo Mazzucchi Long-term Follow-up of Patients Undergoing Nephrectomy for Urolithiasis International Brazilian Journal of Urology Urolithiasis Nephrectomy Glomerular Filtration Rate |
| title | Long-term Follow-up of Patients Undergoing Nephrectomy for Urolithiasis |
| title_full | Long-term Follow-up of Patients Undergoing Nephrectomy for Urolithiasis |
| title_fullStr | Long-term Follow-up of Patients Undergoing Nephrectomy for Urolithiasis |
| title_full_unstemmed | Long-term Follow-up of Patients Undergoing Nephrectomy for Urolithiasis |
| title_short | Long-term Follow-up of Patients Undergoing Nephrectomy for Urolithiasis |
| title_sort | long term follow up of patients undergoing nephrectomy for urolithiasis |
| topic | Urolithiasis Nephrectomy Glomerular Filtration Rate |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382025000100402&lng=en&tlng=en |
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