Disseminated Tuberculosis Mimicking Ankylosing Spondylitis

Ankylosing spondylitis is a chronic inflammatory disorder affecting mainly the axial skeleton. Here we report a case of a man with a clinical suspicion of ankylosing spondylitis but with a persistence of increased inflammatory markers. In this case, 18F-FDG-PET/CT revealed multiple hypermetabolic le...

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Main Authors: Valérie Huyge, Serge Goldman, Muhammad S. Soyfoo
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Case Reports in Rheumatology
Online Access:http://dx.doi.org/10.1155/2011/195085
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author Valérie Huyge
Serge Goldman
Muhammad S. Soyfoo
author_facet Valérie Huyge
Serge Goldman
Muhammad S. Soyfoo
author_sort Valérie Huyge
collection DOAJ
description Ankylosing spondylitis is a chronic inflammatory disorder affecting mainly the axial skeleton. Here we report a case of a man with a clinical suspicion of ankylosing spondylitis but with a persistence of increased inflammatory markers. In this case, 18F-FDG-PET/CT revealed multiple hypermetabolic lesions in axial skeleton, lymph nodes, and the lung, suggestive of either disseminated tuberculosis or lymphoma. Histological analysis of the pulmonary lesion revealed mycobacterium tuberculosis. This case highlights, firstly, the importance of excluding other diagnoses in the presence of clinical picture of ankylosing spondylitis and high inflammatory markers and, secondly, the determining role of PET/CT.
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spelling doaj-art-da1a99134a8e440f99f00821715f8cb72025-02-03T01:21:58ZengWileyCase Reports in Rheumatology2090-68892090-68972011-01-01201110.1155/2011/195085195085Disseminated Tuberculosis Mimicking Ankylosing SpondylitisValérie Huyge0Serge Goldman1Muhammad S. Soyfoo2Department of Nuclear Medicine, Hôpital Erasme, Université Libre de Bruxelles (ULB), 1070 Brussels, BelgiumDepartment of Nuclear Medicine, Hôpital Erasme, Université Libre de Bruxelles (ULB), 1070 Brussels, BelgiumDepartment of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles (ULB), 1070 Brussels, BelgiumAnkylosing spondylitis is a chronic inflammatory disorder affecting mainly the axial skeleton. Here we report a case of a man with a clinical suspicion of ankylosing spondylitis but with a persistence of increased inflammatory markers. In this case, 18F-FDG-PET/CT revealed multiple hypermetabolic lesions in axial skeleton, lymph nodes, and the lung, suggestive of either disseminated tuberculosis or lymphoma. Histological analysis of the pulmonary lesion revealed mycobacterium tuberculosis. This case highlights, firstly, the importance of excluding other diagnoses in the presence of clinical picture of ankylosing spondylitis and high inflammatory markers and, secondly, the determining role of PET/CT.http://dx.doi.org/10.1155/2011/195085
spellingShingle Valérie Huyge
Serge Goldman
Muhammad S. Soyfoo
Disseminated Tuberculosis Mimicking Ankylosing Spondylitis
Case Reports in Rheumatology
title Disseminated Tuberculosis Mimicking Ankylosing Spondylitis
title_full Disseminated Tuberculosis Mimicking Ankylosing Spondylitis
title_fullStr Disseminated Tuberculosis Mimicking Ankylosing Spondylitis
title_full_unstemmed Disseminated Tuberculosis Mimicking Ankylosing Spondylitis
title_short Disseminated Tuberculosis Mimicking Ankylosing Spondylitis
title_sort disseminated tuberculosis mimicking ankylosing spondylitis
url http://dx.doi.org/10.1155/2011/195085
work_keys_str_mv AT valeriehuyge disseminatedtuberculosismimickingankylosingspondylitis
AT sergegoldman disseminatedtuberculosismimickingankylosingspondylitis
AT muhammadssoyfoo disseminatedtuberculosismimickingankylosingspondylitis