Primary Adrenal Failure due to Antiphospholipid Syndrome
Background. Antiphospholipid syndrome (APS) characterized by thrombosis and abortus may rarely cause primary adrenal failure. Case Presentations. A 34-year-old male presented with hypotension, hypoglycemia, hyperpigmentation on his skin and oral mucosa, scars on both legs, and loss of consciousness....
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/161497 |
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| author | Murat Sahin Ayten Oguz Dilek Tuzun Serife Nur Boysan Bülent Mese Hatice Sahin Kamile Gul |
| author_facet | Murat Sahin Ayten Oguz Dilek Tuzun Serife Nur Boysan Bülent Mese Hatice Sahin Kamile Gul |
| author_sort | Murat Sahin |
| collection | DOAJ |
| description | Background. Antiphospholipid syndrome (APS) characterized by thrombosis and abortus may rarely cause primary adrenal failure. Case Presentations. A 34-year-old male presented with hypotension, hypoglycemia, hyperpigmentation on his skin and oral mucosa, scars on both legs, and loss of consciousness. In laboratory examinations, hyponatremia (135 mmol/L), hyperpotassemia (6 mmol/L), and thrombocytopenia (83 K/µL) were determined. Cortisol (1.91 µg/dL) and adrenocorticotropic (550 pg/mL) hormone levels were also evaluated. The patient was hospitalized with a diagnosis of acute adrenal crisis due to primary adrenal insufficiency. A Doppler ultrasound revealed venous thrombosis. The patient was diagnosed with antiphospholipid syndrome after the detection of venous thrombosis, thrombocytopenia, elevated aPTT, and anticardiolipin antibody levels. Anticoagulation treatment was started for antiphospholipid syndrome. The patient is now following up with hydrocortisone, fludrocortisone, and warfarin sodium. Conclusion. Antiphospholipid syndrome is a rare reason for adrenal failure. Antiphospholipid syndrome should be suspected if patients have morbidity secondary to venous-arterial thrombosis. |
| format | Article |
| id | doaj-art-d9fe1876d9654b7ca4adef35f2eb5bde |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-d9fe1876d9654b7ca4adef35f2eb5bde2025-02-03T01:09:04ZengWileyCase Reports in Endocrinology2090-65012090-651X2015-01-01201510.1155/2015/161497161497Primary Adrenal Failure due to Antiphospholipid SyndromeMurat Sahin0Ayten Oguz1Dilek Tuzun2Serife Nur Boysan3Bülent Mese4Hatice Sahin5Kamile Gul6Department of Endocrinology and Metabolism, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 4600 Kahramanmaras, TurkeyDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 4600 Kahramanmaras, TurkeyDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 4600 Kahramanmaras, TurkeyClinic of Endocrinology and Metabolism, Necip Fazil State Hospital, 46050 Kahramanmaras, TurkeyDepartment of Cardiovascular Surgery, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 4600 Kahramanmaras, TurkeyClinic of Chest Diseases, Necip Fazil State Hospital, 46050 Kahramanmaras, TurkeyDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 4600 Kahramanmaras, TurkeyBackground. Antiphospholipid syndrome (APS) characterized by thrombosis and abortus may rarely cause primary adrenal failure. Case Presentations. A 34-year-old male presented with hypotension, hypoglycemia, hyperpigmentation on his skin and oral mucosa, scars on both legs, and loss of consciousness. In laboratory examinations, hyponatremia (135 mmol/L), hyperpotassemia (6 mmol/L), and thrombocytopenia (83 K/µL) were determined. Cortisol (1.91 µg/dL) and adrenocorticotropic (550 pg/mL) hormone levels were also evaluated. The patient was hospitalized with a diagnosis of acute adrenal crisis due to primary adrenal insufficiency. A Doppler ultrasound revealed venous thrombosis. The patient was diagnosed with antiphospholipid syndrome after the detection of venous thrombosis, thrombocytopenia, elevated aPTT, and anticardiolipin antibody levels. Anticoagulation treatment was started for antiphospholipid syndrome. The patient is now following up with hydrocortisone, fludrocortisone, and warfarin sodium. Conclusion. Antiphospholipid syndrome is a rare reason for adrenal failure. Antiphospholipid syndrome should be suspected if patients have morbidity secondary to venous-arterial thrombosis.http://dx.doi.org/10.1155/2015/161497 |
| spellingShingle | Murat Sahin Ayten Oguz Dilek Tuzun Serife Nur Boysan Bülent Mese Hatice Sahin Kamile Gul Primary Adrenal Failure due to Antiphospholipid Syndrome Case Reports in Endocrinology |
| title | Primary Adrenal Failure due to Antiphospholipid Syndrome |
| title_full | Primary Adrenal Failure due to Antiphospholipid Syndrome |
| title_fullStr | Primary Adrenal Failure due to Antiphospholipid Syndrome |
| title_full_unstemmed | Primary Adrenal Failure due to Antiphospholipid Syndrome |
| title_short | Primary Adrenal Failure due to Antiphospholipid Syndrome |
| title_sort | primary adrenal failure due to antiphospholipid syndrome |
| url | http://dx.doi.org/10.1155/2015/161497 |
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