Integrating network pharmacology, molecular docking and non-targeted serum metabolomics to illustrate pharmacodynamic ingredients and pharmacologic mechanism of Haizao Yuhu Decoction in treating hyperthyroidism

Integrating network pharmacology, molecular docking and non-targeted serum metabolomics to illustrate pharmacodynamic ingredients and pharmacologic mechanism of Haizao Yuhu Decoction in treating hyperthyroidism

ObjectiveTo explore the pharmacodynamic ingredients and pharmacologic mechanism of Haizao Yuhu Decoction (HYD) in treating hyperthyroidism via an analysis integrating network pharmacology, molecular docking, and non-targeted serum metabolomics.MethodsTherapeutic targets of hyperthyroidism were searc...

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Bibliographic Details
Main Authors: Wenbin Huang, Xiaoju Liu, Xingjia Li, Ruixiang Zhang, Guofang Chen, Xiaodong Mao, Shuhang Xu, Chao Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Endocrinology
Subjects:
Haizao Yuhu Decoction
hyperthyroidism
network pharmacology
molecular docking
non-targeted serum metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1438821/full
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