Spectrscopic and Conductometric Analysis of Gabapentin
Four simple, sensitive and reproducible methods were developed for the determination of gabapentin (GPT) in pure form and in pharmaceutical preparations. Methods A and B are based on the reaction of cupric chloride with gabapentin to form stable complex, which could be measured spectrophotometricall...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/190517 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558280133574656 |
|---|---|
| author | Sara M. Anis Mervat M. Hosny Hisham E. Abdellatef Mohamed N. El-Balkiny |
| author_facet | Sara M. Anis Mervat M. Hosny Hisham E. Abdellatef Mohamed N. El-Balkiny |
| author_sort | Sara M. Anis |
| collection | DOAJ |
| description | Four simple, sensitive and reproducible methods were developed for the determination of gabapentin (GPT) in pure form and in pharmaceutical preparations. Methods A and B are based on the reaction of cupric chloride with gabapentin to form stable complex, which could be measured spectrophotometrically at λmax 246 nm (method A) or by using conductometric technique (method B). While method C and D depends on the formation of ion pair complex between the studied drug and bromothymol blue, bromocresol green respectively this was extractable with methylene chloride. The concentration ranges were 40-95 μg mL-1, 1-15 mg, 100-800 and 10-150 μg mL-1 for methods A, B, C and D respectively .The optimization of various experimental conditions were described .The results obtained showed good recoveries, Ringbom optimum concentration ranges were calculated, in addition to molar absorptivity and sandell’s sensitivity, detection and quantification limits. The methods were successfully applied to the determination of GPT in bulk and pharmaceutical preparations. The results were favorably comparable with the official method. The molar combining ratio for methods (A-B) was found to be (2:1) (drug: reagent) while for method (C-D) it was found to be (1:1). |
| format | Article |
| id | doaj-art-d9f1a26bcf0b4de7baba5c9a36d721ca |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-d9f1a26bcf0b4de7baba5c9a36d721ca2025-02-03T01:32:54ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-01841784179610.1155/2011/190517Spectrscopic and Conductometric Analysis of GabapentinSara M. Anis0Mervat M. Hosny1Hisham E. Abdellatef2Mohamed N. El-Balkiny3Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, EgyptAnalytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, EgyptAnalytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, EgyptAnalytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, EgyptFour simple, sensitive and reproducible methods were developed for the determination of gabapentin (GPT) in pure form and in pharmaceutical preparations. Methods A and B are based on the reaction of cupric chloride with gabapentin to form stable complex, which could be measured spectrophotometrically at λmax 246 nm (method A) or by using conductometric technique (method B). While method C and D depends on the formation of ion pair complex between the studied drug and bromothymol blue, bromocresol green respectively this was extractable with methylene chloride. The concentration ranges were 40-95 μg mL-1, 1-15 mg, 100-800 and 10-150 μg mL-1 for methods A, B, C and D respectively .The optimization of various experimental conditions were described .The results obtained showed good recoveries, Ringbom optimum concentration ranges were calculated, in addition to molar absorptivity and sandell’s sensitivity, detection and quantification limits. The methods were successfully applied to the determination of GPT in bulk and pharmaceutical preparations. The results were favorably comparable with the official method. The molar combining ratio for methods (A-B) was found to be (2:1) (drug: reagent) while for method (C-D) it was found to be (1:1).http://dx.doi.org/10.1155/2011/190517 |
| spellingShingle | Sara M. Anis Mervat M. Hosny Hisham E. Abdellatef Mohamed N. El-Balkiny Spectrscopic and Conductometric Analysis of Gabapentin E-Journal of Chemistry |
| title | Spectrscopic and Conductometric Analysis of Gabapentin |
| title_full | Spectrscopic and Conductometric Analysis of Gabapentin |
| title_fullStr | Spectrscopic and Conductometric Analysis of Gabapentin |
| title_full_unstemmed | Spectrscopic and Conductometric Analysis of Gabapentin |
| title_short | Spectrscopic and Conductometric Analysis of Gabapentin |
| title_sort | spectrscopic and conductometric analysis of gabapentin |
| url | http://dx.doi.org/10.1155/2011/190517 |
| work_keys_str_mv | AT saramanis spectrscopicandconductometricanalysisofgabapentin AT mervatmhosny spectrscopicandconductometricanalysisofgabapentin AT hishameabdellatef spectrscopicandconductometricanalysisofgabapentin AT mohamednelbalkiny spectrscopicandconductometricanalysisofgabapentin |