Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) for extensive vulvar and vaginal Bowen's disease: A case report
Bowen's disease (BD) is an intraepithelial squamous cell carcinoma (SCC) that commonly affects older individuals, with the vulva being a prevalent site in women. Lesions within the vagina pose a particular challenge for surgical treatment, often compromising both functional integrity and cosmes...
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| Format: | Article |
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024005015 |
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| author | Xiaoqing Xiang Yanliang Li Can Shi Runqun Liu Guozhang Ma Yunyun Cao Lianheng Xia Jie Gao |
| author_facet | Xiaoqing Xiang Yanliang Li Can Shi Runqun Liu Guozhang Ma Yunyun Cao Lianheng Xia Jie Gao |
| author_sort | Xiaoqing Xiang |
| collection | DOAJ |
| description | Bowen's disease (BD) is an intraepithelial squamous cell carcinoma (SCC) that commonly affects older individuals, with the vulva being a prevalent site in women. Lesions within the vagina pose a particular challenge for surgical treatment, often compromising both functional integrity and cosmesis. Photodynamic therapy (PDT) is an emerging, safe, and non-invasive technique utilizing a photosensitizer and a specific light source, widely applied in the treatment of malignancies and skin diseases. We report the case of a 74-year-old woman presenting with a large, dark brown patch on the vulva, histopathologically confirmed as BD. The patient also had lesions within the vagina. Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) was administered, with an optical fiber used for targeted treatment of the vaginal lesions. Complete resolution of the lesions was observed after a single treatment. A follow-up biopsy at 7 months post-treatment revealed no residual tumor cells. The patient remains disease-free at 2 years follow-up and continues to be monitored. This case suggests that HpD-PDT is a viable treatment option for BD, and may be particularly advantageous for elderly patients with extensive or vaginally located lesions, where preserving function and cosmesis is paramount. |
| format | Article |
| id | doaj-art-d9e10279f3694e08a47dd870c5df172f |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-d9e10279f3694e08a47dd870c5df172f2025-02-01T04:11:48ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104465Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) for extensive vulvar and vaginal Bowen's disease: A case reportXiaoqing Xiang0Yanliang Li1Can Shi2Runqun Liu3Guozhang Ma4Yunyun Cao5Lianheng Xia6Jie Gao7Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaBeijing University of Chinese Medicine Shenzhen Hospital (Longgang), Shenzhen, ChinaHeilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaHeilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaHeilongjiang Provincial Hospital, Dermatology Department, Harbin, Heilongjiang, ChinaHeilongjiang Provincial Hospital, Dermatology Department, Harbin, Heilongjiang, ChinaDepartment of Peripheral Vascular Diseases, First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, ChinaDepartment of Peripheral Vascular Diseases, First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China; Corresponding author.Bowen's disease (BD) is an intraepithelial squamous cell carcinoma (SCC) that commonly affects older individuals, with the vulva being a prevalent site in women. Lesions within the vagina pose a particular challenge for surgical treatment, often compromising both functional integrity and cosmesis. Photodynamic therapy (PDT) is an emerging, safe, and non-invasive technique utilizing a photosensitizer and a specific light source, widely applied in the treatment of malignancies and skin diseases. We report the case of a 74-year-old woman presenting with a large, dark brown patch on the vulva, histopathologically confirmed as BD. The patient also had lesions within the vagina. Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) was administered, with an optical fiber used for targeted treatment of the vaginal lesions. Complete resolution of the lesions was observed after a single treatment. A follow-up biopsy at 7 months post-treatment revealed no residual tumor cells. The patient remains disease-free at 2 years follow-up and continues to be monitored. This case suggests that HpD-PDT is a viable treatment option for BD, and may be particularly advantageous for elderly patients with extensive or vaginally located lesions, where preserving function and cosmesis is paramount.http://www.sciencedirect.com/science/article/pii/S1572100024005015Bowen diseaseHematoporphyrine derivativePhotodynamic therapyRunjidan oil |
| spellingShingle | Xiaoqing Xiang Yanliang Li Can Shi Runqun Liu Guozhang Ma Yunyun Cao Lianheng Xia Jie Gao Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) for extensive vulvar and vaginal Bowen's disease: A case report Photodiagnosis and Photodynamic Therapy Bowen disease Hematoporphyrine derivative Photodynamic therapy Runjidan oil |
| title | Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) for extensive vulvar and vaginal Bowen's disease: A case report |
| title_full | Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) for extensive vulvar and vaginal Bowen's disease: A case report |
| title_fullStr | Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) for extensive vulvar and vaginal Bowen's disease: A case report |
| title_full_unstemmed | Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) for extensive vulvar and vaginal Bowen's disease: A case report |
| title_short | Hematoporphyrin derivative-photodynamic therapy (HpD-PDT) for extensive vulvar and vaginal Bowen's disease: A case report |
| title_sort | hematoporphyrin derivative photodynamic therapy hpd pdt for extensive vulvar and vaginal bowen s disease a case report |
| topic | Bowen disease Hematoporphyrine derivative Photodynamic therapy Runjidan oil |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024005015 |
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