Fractionated stereotactic radiotherapy in people with drug-resistant focal epilepsy: first-in-human experience with a healthy tissue-preserving dose-fractionation concept

Fractionated stereotactic radiotherapy in people with drug-resistant focal epilepsy: first-in-human experience with a healthy tissue-preserving dose-fractionation concept

ObjectiveStereotactic radiosurgery (SRS) emerges as a non-surgical treatment option for drug-resistant non-neoplastic focal epilepsy. Previous studies have reported that in about 20% of patients treated with radiotherapy, however, subsequent salvage surgery is required, among other because of sympto...

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Main Authors: Cas Stefaan Dejonckheere, Attila Rácz, Gustavo Renato Sarria, Julian Philipp Layer, Younèss Nour, Lara Caglayan, Molina Grimmer, Victoria Volkenborn, Fabian Kugel, Thomas Müdder, Tobias Baumgartner, Valeri Borger, Alexander Radbruch, Hartmut Vatter, Frank Anton Giordano, Eleni Gkika, Rainer Surges, Davide Scafa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Neurology
Subjects:
epileptic seizures
fractionated stereotactic radiotherapy
stereotactic radiosurgery
non-invasive
epilepsy
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1600381/full
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