Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants
Background Ventricular repolarization time (ECG QT and JT intervals) is associated with malignant arrhythmia. Genome‐wide association studies have identified 230 independent loci for QT and JT; however, 50% of their heritability remains unexplained. Previous work supports a causal effect of lower se...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-09-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.034760 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850220312768020480 |
|---|---|
| author | William J. Young Peter J. van der Most Traci M. Bartz Maxime M. Bos Ginevra Biino ThuyVy Duong Luisa Foco Jesus T. Lominchar Martina Müller‐Nurasyid Giuseppe Giovanni Nardone Alessandro Pecori Julia Ramirez Linda Repetto Katharina Schramm Xia Shen Stefan van Duijvenboden Diana van Heemst Stefan Weiss Jie Yao Jan‐Walter Benjamins Alvaro Alonso Beatrice Spedicati Mary L. Biggs Jennifer A. Brody Marcus Dörr Christian Fuchsberger Martin Gögele Xiuqing Guo M. Arfan Ikram J. Wouter Jukema Stefan Kääb Jørgen K. Kanters Henry J. Lin Allan Linneberg Matthias Nauck Ilja M. Nolte Giulia Pianigiani Aurora Santin Elsayed Z. Soliman Paola Tesolin Simona Vaccargiu Melanie Waldenberger Pim van der Harst Niek Verweij Dan E. Arking Maria Pina Concas Alessandro De Grandi Giorgia Girotto Niels Grarup Maryam Kavousi Dennis O. Mook‐Kanamori Pau Navarro Michele Orini Sandosh Padmanabhan Cristian Pattaro Annette Peters Mario Pirastu Peter P. Pramstaller Susan R. Heckbert Mortiz Sinner Harold Snieder Uwe Völker James F. Wilson W. James Gauderman Pier D. Lambiase Nona Sotoodehnia Andrew Tinker Helen R. Warren Raymond Noordam Patricia B. Munroe |
| author_facet | William J. Young Peter J. van der Most Traci M. Bartz Maxime M. Bos Ginevra Biino ThuyVy Duong Luisa Foco Jesus T. Lominchar Martina Müller‐Nurasyid Giuseppe Giovanni Nardone Alessandro Pecori Julia Ramirez Linda Repetto Katharina Schramm Xia Shen Stefan van Duijvenboden Diana van Heemst Stefan Weiss Jie Yao Jan‐Walter Benjamins Alvaro Alonso Beatrice Spedicati Mary L. Biggs Jennifer A. Brody Marcus Dörr Christian Fuchsberger Martin Gögele Xiuqing Guo M. Arfan Ikram J. Wouter Jukema Stefan Kääb Jørgen K. Kanters Henry J. Lin Allan Linneberg Matthias Nauck Ilja M. Nolte Giulia Pianigiani Aurora Santin Elsayed Z. Soliman Paola Tesolin Simona Vaccargiu Melanie Waldenberger Pim van der Harst Niek Verweij Dan E. Arking Maria Pina Concas Alessandro De Grandi Giorgia Girotto Niels Grarup Maryam Kavousi Dennis O. Mook‐Kanamori Pau Navarro Michele Orini Sandosh Padmanabhan Cristian Pattaro Annette Peters Mario Pirastu Peter P. Pramstaller Susan R. Heckbert Mortiz Sinner Harold Snieder Uwe Völker James F. Wilson W. James Gauderman Pier D. Lambiase Nona Sotoodehnia Andrew Tinker Helen R. Warren Raymond Noordam Patricia B. Munroe |
| author_sort | William J. Young |
| collection | DOAJ |
| description | Background Ventricular repolarization time (ECG QT and JT intervals) is associated with malignant arrhythmia. Genome‐wide association studies have identified 230 independent loci for QT and JT; however, 50% of their heritability remains unexplained. Previous work supports a causal effect of lower serum calcium concentrations on longer ventricular repolarization time. We hypothesized calcium interactions with QT and JT variant associations could explain a proportion of the missing heritability. Methods and Results We performed genome‐wide calcium interaction analyses for QT and JT intervals. Participants were stratified by their calcium level relative to the study distribution (top or bottom 20%). We performed a 2‐stage analysis (genome‐wide discovery [N=62 532] and replication [N=59 861] of lead variants) and a single‐stage genome‐wide meta‐analysis (N=122 393, [European ancestry N=117 581, African ancestry N=4812]). We also calculated 2‐degrees of freedom joint main and interaction and 1‐degree of freedom interaction P values. In 2‐stage and single‐stage analyses, 50 and 98 independent loci, respectively, were associated with either QT or JT intervals (2‐degrees of freedom joint main and interaction P value <5×10−8). No lead variant had a significant interaction result after correcting for multiple testing and sensitivity analyses provided similar findings. Two loci in the single‐stage meta‐analysis were not reported previously (SPPL2B and RFX6). Conclusions We have found limited support for an interaction effect of serum calcium on QT and JT variant associations despite sample sizes with suitable power to detect relevant effects. Therefore, such effects are unlikely to explain a meaningful proportion of the heritability of QT and JT, and factors including rare variation and other environmental interactions need to be considered. |
| format | Article |
| id | doaj-art-d9db835045cc4f1b993097b3854693a3 |
| institution | OA Journals |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-d9db835045cc4f1b993097b3854693a32025-08-20T02:07:06ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-09-01131710.1161/JAHA.123.034760Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 ParticipantsWilliam J. Young0Peter J. van der Most1Traci M. Bartz2Maxime M. Bos3Ginevra Biino4ThuyVy Duong5Luisa Foco6Jesus T. Lominchar7Martina Müller‐Nurasyid8Giuseppe Giovanni Nardone9Alessandro Pecori10Julia Ramirez11Linda Repetto12Katharina Schramm13Xia Shen14Stefan van Duijvenboden15Diana van Heemst16Stefan Weiss17Jie Yao18Jan‐Walter Benjamins19Alvaro Alonso20Beatrice Spedicati21Mary L. Biggs22Jennifer A. Brody23Marcus Dörr24Christian Fuchsberger25Martin Gögele26Xiuqing Guo27M. Arfan Ikram28J. Wouter Jukema29Stefan Kääb30Jørgen K. Kanters31Henry J. Lin32Allan Linneberg33Matthias Nauck34Ilja M. Nolte35Giulia Pianigiani36Aurora Santin37Elsayed Z. Soliman38Paola Tesolin39Simona Vaccargiu40Melanie Waldenberger41Pim van der Harst42Niek Verweij43Dan E. Arking44Maria Pina Concas45Alessandro De Grandi46Giorgia Girotto47Niels Grarup48Maryam Kavousi49Dennis O. Mook‐Kanamori50Pau Navarro51Michele Orini52Sandosh Padmanabhan53Cristian Pattaro54Annette Peters55Mario Pirastu56Peter P. Pramstaller57Susan R. Heckbert58Mortiz Sinner59Harold Snieder60Uwe Völker61James F. Wilson62W. James Gauderman63Pier D. Lambiase64Nona Sotoodehnia65Andrew Tinker66Helen R. Warren67Raymond Noordam68Patricia B. Munroe69Clinical Pharmacology and Precision Medicine William Harvey Research Institute, Queen Mary University of London United KingdomDepartment of Epidemiology University of Groningen, University Medical Center Groningen Groningen The NetherlandsCardiovascular Health Research Unit, Department of Biostatistics and Medicine University of Washington Seattle WA USADepartment of Epidemiology Erasmus MC University Medical Center Rotterdam NetherlandsInstitute of Molecular Genetics, National Research Council of Italy Pavia ItalyDepartment of Genetic Medicine McKusick‐Nathans Institute, Johns Hopkins University School of Medicine Baltimore MD USAEurac Research Institute for Biomedicine (Affiliated with the University of Lübeck) Bolzano ItalyNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences University of Copenhagen DenmarkGerman Research Center for Environmental Health Institute of Genetic Epidemiology, Helmholtz Zentrum München Neuherberg GermanyDepartment of Medicine, Surgery and Health Sciences University of Trieste ItalyInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo” Trieste ItalyClinical Pharmacology and Precision Medicine William Harvey Research Institute, Queen Mary University of London United KingdomCentre for Global Health Research Usher Institute, University of Edinburgh ScotlandGerman Research Center for Environmental Health Institute of Genetic Epidemiology, Helmholtz Zentrum München Neuherberg GermanyCentre for Global Health Research Usher Institute, University of Edinburgh ScotlandClinical Pharmacology and Precision Medicine William Harvey Research Institute, Queen Mary University of London United KingdomDepartment of Internal Medicine, Section of Gerontology and Geriatrics Leiden University Medical Center Leiden The NetherlandsDZHK (German Centre for Cardiovascular Research), partner site Greifswald Greifswald GermanyDepartment of Pediatrics The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor‐UCLA Medical Center Torrance CA USADepartment of Cardiology University of Groningen, University Medical Center Groningen Groningen The NetherlandsDepartment of Epidemiology Rollins School of Public Health, Emory University Atlanta GA USADepartment of Medicine, Surgery and Health Sciences University of Trieste ItalyCardiovascular Health Research Unit, Department of Medicine University of Washington Seattle WA USACardiovascular Health Research Unit, Department of Medicine University of Washington Seattle WA USADZHK (German Centre for Cardiovascular Research), partner site Greifswald Greifswald GermanyEurac Research Institute for Biomedicine (Affiliated with the University of Lübeck) Bolzano ItalyEurac Research Institute for Biomedicine (Affiliated with the University of Lübeck) Bolzano ItalyInstitute for Translational Genomics and Population Sciences/The Lundquist Institute at Harbor‐UCLA Medical Center Torrance CA USADepartment of Epidemiology Erasmus MC University Medical Center Rotterdam NetherlandsDepartment of Cardiology Leiden University Medical Center Leiden The NetherlandsDepartment of Cardiology University Hospital, LMU Munich Munich GermanyLaboratory of Experimental Cardiology, Department of Biomedical Sciences University of Copenhagen DenmarkDepartment of Pediatrics The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor‐UCLA Medical Center Torrance CA USACenter for Clinical Research and Prevention Bispebjerg and Frederiksberg Hospital, The Capital Region Copenhagen DenmarkDZHK (German Centre for Cardiovascular Research), partner site Greifswald Greifswald GermanyDepartment of Epidemiology University of Groningen, University Medical Center Groningen Groningen The NetherlandsInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo” Trieste ItalyDepartment of Medicine, Surgery and Health Sciences University of Trieste ItalyEpidemiological Cardiology Research Center (EPICARE) Wake Forest School of Medicine Winston Salem USAInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo” Trieste ItalyInstitute for Genetic and Biomedical Research, National Research Council of Italy Cagliari ItalyDZHK (German Centre for Cardiovascular Research), partner site: Munich Heart Alliance Munich GermanyDepartment of Cardiology University of Groningen, University Medical Center Groningen Groningen The NetherlandsDepartment of Cardiology University of Groningen, University Medical Center Groningen Groningen The NetherlandsDepartment of Genetic Medicine McKusick‐Nathans Institute, Johns Hopkins University School of Medicine Baltimore MD USAInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo” Trieste ItalyEurac Research Institute for Biomedicine (Affiliated with the University of Lübeck) Bolzano ItalyDepartment of Medicine, Surgery and Health Sciences University of Trieste ItalyNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences University of Copenhagen DenmarkDepartment of Epidemiology Erasmus MC University Medical Center Rotterdam NetherlandsDepartment of Clinical Epidemiology Leiden University Medical Center Leiden The NetherlandsMRC Human Genetics Unit Institute of Genetics and Cancer, University of Edinburgh ScotlandBarts Heart Centre St Bartholomew’s Hospital, Barts Health NHS Trust London United KingdomInstitute of Cardiovascular and Medical Sciences, University of Glasgow UKEurac Research Institute for Biomedicine (Affiliated with the University of Lübeck) Bolzano ItalyGerman Research Center for Environmental Health Institute of Genetic Epidemiology, Helmholtz Zentrum München Neuherberg GermanyInstitute for Genetic and Biomedical Research, Sassari Unit, National Research Council of Italy Sassari ItalyEurac Research Institute for Biomedicine (Affiliated with the University of Lübeck) Bolzano ItalyCardiovascular Health Research Unit, Department of Medicine University of Washington Seattle WA USADepartment of Cardiology University Hospital, LMU Munich Munich GermanyDepartment of Epidemiology University of Groningen, University Medical Center Groningen Groningen The NetherlandsDZHK (German Centre for Cardiovascular Research), partner site Greifswald Greifswald GermanyCentre for Global Health Research Usher Institute, University of Edinburgh ScotlandDepartment of population and public health sciences University of Southern California Los Angeles CA USABarts Heart Centre St Bartholomew’s Hospital, Barts Health NHS Trust London United KingdomCardiovascular Health Research Unit, Division of Cardiology, Department of Medicine University of Washington Seattle WA USAClinical Pharmacology and Precision Medicine William Harvey Research Institute, Queen Mary University of London United KingdomClinical Pharmacology and Precision Medicine William Harvey Research Institute, Queen Mary University of London United KingdomDepartment of Internal Medicine, Section of Gerontology and Geriatrics Leiden University Medical Center Leiden The NetherlandsClinical Pharmacology and Precision Medicine William Harvey Research Institute, Queen Mary University of London United KingdomBackground Ventricular repolarization time (ECG QT and JT intervals) is associated with malignant arrhythmia. Genome‐wide association studies have identified 230 independent loci for QT and JT; however, 50% of their heritability remains unexplained. Previous work supports a causal effect of lower serum calcium concentrations on longer ventricular repolarization time. We hypothesized calcium interactions with QT and JT variant associations could explain a proportion of the missing heritability. Methods and Results We performed genome‐wide calcium interaction analyses for QT and JT intervals. Participants were stratified by their calcium level relative to the study distribution (top or bottom 20%). We performed a 2‐stage analysis (genome‐wide discovery [N=62 532] and replication [N=59 861] of lead variants) and a single‐stage genome‐wide meta‐analysis (N=122 393, [European ancestry N=117 581, African ancestry N=4812]). We also calculated 2‐degrees of freedom joint main and interaction and 1‐degree of freedom interaction P values. In 2‐stage and single‐stage analyses, 50 and 98 independent loci, respectively, were associated with either QT or JT intervals (2‐degrees of freedom joint main and interaction P value <5×10−8). No lead variant had a significant interaction result after correcting for multiple testing and sensitivity analyses provided similar findings. Two loci in the single‐stage meta‐analysis were not reported previously (SPPL2B and RFX6). Conclusions We have found limited support for an interaction effect of serum calcium on QT and JT variant associations despite sample sizes with suitable power to detect relevant effects. Therefore, such effects are unlikely to explain a meaningful proportion of the heritability of QT and JT, and factors including rare variation and other environmental interactions need to be considered.https://www.ahajournals.org/doi/10.1161/JAHA.123.034760calciumECG intervalsgene‐lifestyle interactiongenome‐wide association studyventricular repolarization |
| spellingShingle | William J. Young Peter J. van der Most Traci M. Bartz Maxime M. Bos Ginevra Biino ThuyVy Duong Luisa Foco Jesus T. Lominchar Martina Müller‐Nurasyid Giuseppe Giovanni Nardone Alessandro Pecori Julia Ramirez Linda Repetto Katharina Schramm Xia Shen Stefan van Duijvenboden Diana van Heemst Stefan Weiss Jie Yao Jan‐Walter Benjamins Alvaro Alonso Beatrice Spedicati Mary L. Biggs Jennifer A. Brody Marcus Dörr Christian Fuchsberger Martin Gögele Xiuqing Guo M. Arfan Ikram J. Wouter Jukema Stefan Kääb Jørgen K. Kanters Henry J. Lin Allan Linneberg Matthias Nauck Ilja M. Nolte Giulia Pianigiani Aurora Santin Elsayed Z. Soliman Paola Tesolin Simona Vaccargiu Melanie Waldenberger Pim van der Harst Niek Verweij Dan E. Arking Maria Pina Concas Alessandro De Grandi Giorgia Girotto Niels Grarup Maryam Kavousi Dennis O. Mook‐Kanamori Pau Navarro Michele Orini Sandosh Padmanabhan Cristian Pattaro Annette Peters Mario Pirastu Peter P. Pramstaller Susan R. Heckbert Mortiz Sinner Harold Snieder Uwe Völker James F. Wilson W. James Gauderman Pier D. Lambiase Nona Sotoodehnia Andrew Tinker Helen R. Warren Raymond Noordam Patricia B. Munroe Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease calcium ECG intervals gene‐lifestyle interaction genome‐wide association study ventricular repolarization |
| title | Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants |
| title_full | Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants |
| title_fullStr | Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants |
| title_full_unstemmed | Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants |
| title_short | Genome‐Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants |
| title_sort | genome wide interaction analyses of serum calcium on ventricular repolarization time in 125 393 participants |
| topic | calcium ECG intervals gene‐lifestyle interaction genome‐wide association study ventricular repolarization |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.034760 |
| work_keys_str_mv | AT williamjyoung genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT peterjvandermost genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT tracimbartz genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT maximembos genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT ginevrabiino genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT thuyvyduong genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT luisafoco genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT jesustlominchar genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT martinamullernurasyid genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT giuseppegiovanninardone genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT alessandropecori genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT juliaramirez genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT lindarepetto genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT katharinaschramm genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT xiashen genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT stefanvanduijvenboden genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT dianavanheemst genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT stefanweiss genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT jieyao genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT janwalterbenjamins genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT alvaroalonso genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT beatricespedicati genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT marylbiggs genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT jenniferabrody genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT marcusdorr genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT christianfuchsberger genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT martingogele genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT xiuqingguo genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT marfanikram genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT jwouterjukema genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT stefankaab genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT jørgenkkanters genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT henryjlin genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT allanlinneberg genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT matthiasnauck genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT iljamnolte genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT giuliapianigiani genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT aurorasantin genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT elsayedzsoliman genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT paolatesolin genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT simonavaccargiu genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT melaniewaldenberger genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT pimvanderharst genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT niekverweij genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT danearking genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT mariapinaconcas genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT alessandrodegrandi genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT giorgiagirotto genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT nielsgrarup genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT maryamkavousi genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT dennisomookkanamori genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT paunavarro genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT micheleorini genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT sandoshpadmanabhan genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT cristianpattaro genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT annettepeters genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT mariopirastu genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT peterppramstaller genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT susanrheckbert genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT mortizsinner genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT haroldsnieder genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT uwevolker genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT jamesfwilson genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT wjamesgauderman genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT pierdlambiase genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT nonasotoodehnia genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT andrewtinker genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT helenrwarren genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT raymondnoordam genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants AT patriciabmunroe genomewideinteractionanalysesofserumcalciumonventricularrepolarizationtimein125393participants |