KLF4 overexpression protects against complement-mediated endothelial injury in transplant-associated thrombotic microangiopathy

KLF4 overexpression protects against complement-mediated endothelial injury in transplant-associated thrombotic microangiopathy

Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe complication of hematopoietic stem cell transplantation, marked by excessive complement activation, endothelial injury, and microangiopathy. Although complement blockade benefits some patients, effective prophylactic and therapeu...

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Main Authors: Shuhui Jiang, Jiaqian Qi, Tingting Pan, Zhenzhen Yao, Siyi Lu, Yifei Han, Depei Wu, Yue Han
Format: Article
Language:English
Published: Ferrata Storti Foundation 2025-08-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/12207
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https://haematologica.org/article/view/12207

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