The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana
Background. Bloodstream infections are among the top causes of morbidity and mortality in people of all ages, especially in immunocompromised patients in sub-Saharan Africa. This study aimed at describing the epidemiology of bloodstream infections and antimicrobial susceptibility pattern over a nine...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/6750864 |
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| author | John Gameli Deku Mavis Puopelle Dakorah Sylvester Yao Lokpo Verner N. Orish Francis Abeku Ussher Godsway Edem Kpene Vida Angmorkie Eshun Eunice Agyei Waldermer Attivor James Osei-Yeboah |
| author_facet | John Gameli Deku Mavis Puopelle Dakorah Sylvester Yao Lokpo Verner N. Orish Francis Abeku Ussher Godsway Edem Kpene Vida Angmorkie Eshun Eunice Agyei Waldermer Attivor James Osei-Yeboah |
| author_sort | John Gameli Deku |
| collection | DOAJ |
| description | Background. Bloodstream infections are among the top causes of morbidity and mortality in people of all ages, especially in immunocompromised patients in sub-Saharan Africa. This study aimed at describing the epidemiology of bloodstream infections and antimicrobial susceptibility pattern over a nine-year period at St. Dominic Hospital, Akwatia, in the Eastern Region of Ghana. Method. This study retrospectively analysed data from 4,489 patients who were referred to the Laboratory Department for blood culture and sensitivity testing from January 2009 to December 2017. Sociodemographic data included age, gender, and patients’ department. Blood culture results were retrieved from archival records in the laboratory. The authorities of St. Dominic Hospital granted approval for the study. Results. The incidence of bloodstream infection over the 9 years was 51.4 positive cultures per 100,000 hospital attendance. Staphylococcus aureus was the leading causative agent of bacteraemia for the first two scalar years (2009–2011 (38.9%) and 2012–2014 (42.2%)) while coagulase-negative staphylococcus (CoNS) (50.5%) was predominant for the last scalar year (2015–2017), followed by Staphylococcus aureus (169/587 (28.8%)). The highest incidence of bloodstream infections was recorded in the wet seasons (months of May (8.9 per 10,000 persons) and October (10.1 per 10,000 persons)). The bacterial isolates demonstrated high resistance to tetracyclines (390/531 (73.4%)), penicillins (1282/1669 (76.8%)), and sulphonamides (450/499 (90.2%)). Conclusion. Bloodstream infection and antimicrobial resistance are high in patients seeking healthcare in Akwatia. This therefore calls for concerted efforts aimed at reducing the incidence in the study area. |
| format | Article |
| id | doaj-art-d9d8236d4ce14348a94bf3e185c519d1 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-d9d8236d4ce14348a94bf3e185c519d12025-02-03T07:23:32ZengWileyJournal of Tropical Medicine1687-96861687-96942019-01-01201910.1155/2019/67508646750864The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, GhanaJohn Gameli Deku0Mavis Puopelle Dakorah1Sylvester Yao Lokpo2Verner N. Orish3Francis Abeku Ussher4Godsway Edem Kpene5Vida Angmorkie Eshun6Eunice Agyei7Waldermer Attivor8James Osei-Yeboah9Department of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, GhanaLaboratory Department, Cape-Coast Teaching Hospital, Cape-Coast, Central Region, GhanaDepartment of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, GhanaDepartment of Microbiology and Immunology, School of Medicine, University of Health and Allied Sciences, Ho, GhanaFaculty of Health and Allied Sciences, Koforidua Technical University, Koforidua, Eastern Region, GhanaDepartment of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, GhanaLaboratory Department, St. Dominic Hospital, Akwatia, Eastern Region, GhanaLaboratory Department, St. Dominic Hospital, Akwatia, Eastern Region, GhanaLaboratory Department, St. Dominic Hospital, Akwatia, Eastern Region, GhanaDepartment of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, GhanaBackground. Bloodstream infections are among the top causes of morbidity and mortality in people of all ages, especially in immunocompromised patients in sub-Saharan Africa. This study aimed at describing the epidemiology of bloodstream infections and antimicrobial susceptibility pattern over a nine-year period at St. Dominic Hospital, Akwatia, in the Eastern Region of Ghana. Method. This study retrospectively analysed data from 4,489 patients who were referred to the Laboratory Department for blood culture and sensitivity testing from January 2009 to December 2017. Sociodemographic data included age, gender, and patients’ department. Blood culture results were retrieved from archival records in the laboratory. The authorities of St. Dominic Hospital granted approval for the study. Results. The incidence of bloodstream infection over the 9 years was 51.4 positive cultures per 100,000 hospital attendance. Staphylococcus aureus was the leading causative agent of bacteraemia for the first two scalar years (2009–2011 (38.9%) and 2012–2014 (42.2%)) while coagulase-negative staphylococcus (CoNS) (50.5%) was predominant for the last scalar year (2015–2017), followed by Staphylococcus aureus (169/587 (28.8%)). The highest incidence of bloodstream infections was recorded in the wet seasons (months of May (8.9 per 10,000 persons) and October (10.1 per 10,000 persons)). The bacterial isolates demonstrated high resistance to tetracyclines (390/531 (73.4%)), penicillins (1282/1669 (76.8%)), and sulphonamides (450/499 (90.2%)). Conclusion. Bloodstream infection and antimicrobial resistance are high in patients seeking healthcare in Akwatia. This therefore calls for concerted efforts aimed at reducing the incidence in the study area.http://dx.doi.org/10.1155/2019/6750864 |
| spellingShingle | John Gameli Deku Mavis Puopelle Dakorah Sylvester Yao Lokpo Verner N. Orish Francis Abeku Ussher Godsway Edem Kpene Vida Angmorkie Eshun Eunice Agyei Waldermer Attivor James Osei-Yeboah The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana Journal of Tropical Medicine |
| title | The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana |
| title_full | The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana |
| title_fullStr | The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana |
| title_full_unstemmed | The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana |
| title_short | The Epidemiology of Bloodstream Infections and Antimicrobial Susceptibility Patterns: A Nine-Year Retrospective Study at St. Dominic Hospital, Akwatia, Ghana |
| title_sort | epidemiology of bloodstream infections and antimicrobial susceptibility patterns a nine year retrospective study at st dominic hospital akwatia ghana |
| url | http://dx.doi.org/10.1155/2019/6750864 |
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