NMDAR inhibitor preconditioned mesenchymal stromal cell-derived extracellular vesicles enhance post-stroke recovery by targeting excitotoxicity and neuronal regeneration

NMDAR inhibitor preconditioned mesenchymal stromal cell-derived extracellular vesicles enhance post-stroke recovery by targeting excitotoxicity and neuronal regeneration

BackgroundStroke is a leading global cause of disability and mortality, with ischemic stroke triggering NMDAR overactivation and excitotoxic neuronal injury. Extracellular vesicles (EVs) derived from stem cells under specific microenvironmental conditions show therapeutic potential for stroke recove...

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Bibliographic Details
Main Authors: XiaoLu Zhang, HuanNa Tian, HaiMei Bo, Li Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
extracellular vesicles
ischemic stroke
excitotoxicity
umbilical cord mesenchymal stem cells
preconditioning
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1608615/full
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