scRNA-Seq reveals age-dependent microglial evolution as a determinant of immune response following spinal cord injury

scRNA-Seq reveals age-dependent microglial evolution as a determinant of immune response following spinal cord injury

Spinal cord injury (SCI) is a debilitating condition of the central nervous system (CNS) that leads to severe impairments in sensory and motor functions. Previous studies have pointed out that patient age is a critical factor influencing SCI prognosis. However, the role of microglia in age-related d...

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Bibliographic Details
Main Authors: Lufei Shao, Yueliang Chang, Jinfang Liu, Leilei Lin, Long Chang, Jialin Zhang, Zhibin Lan, Honglai Zhang, Xiaolei Chen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Brain Research Bulletin
Subjects:
Microglial evolution
Immune response
Age-dependent differences
Spinal cord injury
Single-cell RNA sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923024002508
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