Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular Pathologies
Initially thought to only provide mechanical support for the underlying blood vessels, perivascular adipose tissue (PVAT) has now emerged as a regulator of vascular function. A healthy PVAT exerts anticontractile and anti-inflammatory actions on the underlying vasculature via the release of adipocyt...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/2734321 |
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| author | Afifah Zahirah Abd Rami Adila A. Hamid Nur Najmi Mohamad Anuar Amilia Aminuddin Azizah Ugusman |
| author_facet | Afifah Zahirah Abd Rami Adila A. Hamid Nur Najmi Mohamad Anuar Amilia Aminuddin Azizah Ugusman |
| author_sort | Afifah Zahirah Abd Rami |
| collection | DOAJ |
| description | Initially thought to only provide mechanical support for the underlying blood vessels, perivascular adipose tissue (PVAT) has now emerged as a regulator of vascular function. A healthy PVAT exerts anticontractile and anti-inflammatory actions on the underlying vasculature via the release of adipocytokines such as adiponectin, nitric oxide, and omentin. However, dysfunctional PVAT produces more proinflammatory adipocytokines such as leptin, resistin, interleukin- (IL-) 6, IL-1β, and tumor necrosis factor-alpha, thus inducing an inflammatory response that contributes to the pathogenesis of vascular diseases. In this review, current knowledge on the role of PVAT inflammation in the development of vascular pathologies such as atherosclerosis and hypertension was discussed. |
| format | Article |
| id | doaj-art-d988958a50444f90a493c0477263bd52 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d988958a50444f90a493c0477263bd522025-02-03T07:24:28ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/2734321Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular PathologiesAfifah Zahirah Abd Rami0Adila A. Hamid1Nur Najmi Mohamad Anuar2Amilia Aminuddin3Azizah Ugusman4Department of PhysiologyDepartment of PhysiologyCenter for Toxicology & Health Risk StudiesDepartment of PhysiologyDepartment of PhysiologyInitially thought to only provide mechanical support for the underlying blood vessels, perivascular adipose tissue (PVAT) has now emerged as a regulator of vascular function. A healthy PVAT exerts anticontractile and anti-inflammatory actions on the underlying vasculature via the release of adipocytokines such as adiponectin, nitric oxide, and omentin. However, dysfunctional PVAT produces more proinflammatory adipocytokines such as leptin, resistin, interleukin- (IL-) 6, IL-1β, and tumor necrosis factor-alpha, thus inducing an inflammatory response that contributes to the pathogenesis of vascular diseases. In this review, current knowledge on the role of PVAT inflammation in the development of vascular pathologies such as atherosclerosis and hypertension was discussed.http://dx.doi.org/10.1155/2022/2734321 |
| spellingShingle | Afifah Zahirah Abd Rami Adila A. Hamid Nur Najmi Mohamad Anuar Amilia Aminuddin Azizah Ugusman Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular Pathologies Mediators of Inflammation |
| title | Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular Pathologies |
| title_full | Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular Pathologies |
| title_fullStr | Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular Pathologies |
| title_full_unstemmed | Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular Pathologies |
| title_short | Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular Pathologies |
| title_sort | exploring the relationship of perivascular adipose tissue inflammation and the development of vascular pathologies |
| url | http://dx.doi.org/10.1155/2022/2734321 |
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