Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction
Objective. To describe the dynamics changes of sCD163, soluble serum triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin (PCT), and C-reactive protein (CRP) during the course of sepsis, as well as their outcome prediction. Patients and Methods. An SIRS group (30 cases) and a s...
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/969875 |
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| author | Longxiang Su Lin Feng Qing Song Hongjun Kang Xingang Zhang Zhixin Liang Yanhong Jia Dan Feng Changting Liu Lixin Xie |
| author_facet | Longxiang Su Lin Feng Qing Song Hongjun Kang Xingang Zhang Zhixin Liang Yanhong Jia Dan Feng Changting Liu Lixin Xie |
| author_sort | Longxiang Su |
| collection | DOAJ |
| description | Objective. To describe the dynamics changes of sCD163, soluble serum triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin (PCT), and C-reactive protein (CRP) during the course of sepsis, as well as their outcome prediction. Patients and Methods. An SIRS group (30 cases) and a sepsis group (100 cases) were involved in this study. Based on a 28-day survival, the sepsis was further divided into the survivors’ and nonsurvivors’ groups. Serum sTREM-1, sCD163, PCT, CRP, and WBC counts were tested on days 1, 3, 5, 7, 10, and 14. Results. On the ICU admission, the sepsis group displayed higher levels of sTREM-1, sCD163, PCT, and CRP than the SIRS group (P<0.05). Although PCT and sTREM-1 are good markers to identify severity, sTREM-1 is more reliable, which proved to be a risk factor related to sepsis. During a 14-day observation, sCD163, sTREM-1, PCT, and SOFA scores continued to climb among nonsurvivors, while their WBC and CRP went down. Both sCD163 and SOFA scores are risk factors impacting the survival time. Conclusion. With regard to sepsis diagnosis and severity, sTREM-1 is more ideal and constitutes a risk factor. sCD163 is of a positive value in dynamic prognostic assessment and may be taken as a survival-impacting risk factor. |
| format | Article |
| id | doaj-art-d987d43df01149399c21d96195526416 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d987d43df01149399c21d961955264162025-02-03T01:02:27ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/969875969875Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic PredictionLongxiang Su0Lin Feng1Qing Song2Hongjun Kang3Xingang Zhang4Zhixin Liang5Yanhong Jia6Dan Feng7Changting Liu8Lixin Xie9Department of Respiratory Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaDepartment of Respiratory Medicine, Guangzhou Women and Children Medical Care Center, Guangzhou, Guangdong 510623, ChinaDepartment of Critical Care Medicine, Chinese PLA General Hospital, Beijing 100853, ChinaDepartment of Critical Care Medicine, Chinese PLA General Hospital, Beijing 100853, ChinaDepartment of Respiratory Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaDepartment of Respiratory Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaDepartment of Respiratory Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaDepartment of Medical Statistics, Chinese PLA General Hospital, Beijing 100853, ChinaNanlou Respiratory Disease Department, Chinese PLA General Hospital, Beijing 100853, ChinaDepartment of Respiratory Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaObjective. To describe the dynamics changes of sCD163, soluble serum triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin (PCT), and C-reactive protein (CRP) during the course of sepsis, as well as their outcome prediction. Patients and Methods. An SIRS group (30 cases) and a sepsis group (100 cases) were involved in this study. Based on a 28-day survival, the sepsis was further divided into the survivors’ and nonsurvivors’ groups. Serum sTREM-1, sCD163, PCT, CRP, and WBC counts were tested on days 1, 3, 5, 7, 10, and 14. Results. On the ICU admission, the sepsis group displayed higher levels of sTREM-1, sCD163, PCT, and CRP than the SIRS group (P<0.05). Although PCT and sTREM-1 are good markers to identify severity, sTREM-1 is more reliable, which proved to be a risk factor related to sepsis. During a 14-day observation, sCD163, sTREM-1, PCT, and SOFA scores continued to climb among nonsurvivors, while their WBC and CRP went down. Both sCD163 and SOFA scores are risk factors impacting the survival time. Conclusion. With regard to sepsis diagnosis and severity, sTREM-1 is more ideal and constitutes a risk factor. sCD163 is of a positive value in dynamic prognostic assessment and may be taken as a survival-impacting risk factor.http://dx.doi.org/10.1155/2013/969875 |
| spellingShingle | Longxiang Su Lin Feng Qing Song Hongjun Kang Xingang Zhang Zhixin Liang Yanhong Jia Dan Feng Changting Liu Lixin Xie Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction Mediators of Inflammation |
| title | Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction |
| title_full | Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction |
| title_fullStr | Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction |
| title_full_unstemmed | Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction |
| title_short | Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction |
| title_sort | diagnostic value of dynamics serum scd163 strem 1 pct and crp in differentiating sepsis severity assessment and prognostic prediction |
| url | http://dx.doi.org/10.1155/2013/969875 |
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