The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and Survival
B7-H4 is one of the most recently identified members of B7 superfamily of costimulatory molecules serving as an inhibitory modulator of T-cell response. B7-H4 is broadly expressed in human peripheral tissues and inducibly expressed in immune cells. The expression of B7-H4 has been observed in variou...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/695834 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549200603119616 |
|---|---|
| author | Changjun He Haiquan Qiao Hongchi Jiang Xueying Sun |
| author_facet | Changjun He Haiquan Qiao Hongchi Jiang Xueying Sun |
| author_sort | Changjun He |
| collection | DOAJ |
| description | B7-H4 is one of the most recently identified members of B7 superfamily of costimulatory molecules serving as an inhibitory modulator of T-cell response. B7-H4 is broadly expressed in human peripheral tissues and inducibly expressed in immune cells. The expression of B7-H4 has been observed in various types of human cancer tissues, and its soluble form has been detected in blood samples from cancer patients. However, its precise physiological role is still elusive, as its receptor has not been identified and the expression levels are not consistent. This paper summarizes the pertinent data on the inhibitory role of B7-H4 in antitumor immunity and its association with cancer progression and survival in human patients. The paper also discusses the clinical significance of investigating B7-H4 as potential markers for cancer diagnosis and prognosis, and as therapeutic targets. |
| format | Article |
| id | doaj-art-d982fff2dc6e45ac9eba0076b55f541c |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-d982fff2dc6e45ac9eba0076b55f541c2025-02-03T06:12:03ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/695834695834The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and SurvivalChangjun He0Haiquan Qiao1Hongchi Jiang2Xueying Sun3The Hepatosplenic Surgery Center, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, ChinaThe Hepatosplenic Surgery Center, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, ChinaThe Hepatosplenic Surgery Center, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, ChinaThe Hepatosplenic Surgery Center, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, ChinaB7-H4 is one of the most recently identified members of B7 superfamily of costimulatory molecules serving as an inhibitory modulator of T-cell response. B7-H4 is broadly expressed in human peripheral tissues and inducibly expressed in immune cells. The expression of B7-H4 has been observed in various types of human cancer tissues, and its soluble form has been detected in blood samples from cancer patients. However, its precise physiological role is still elusive, as its receptor has not been identified and the expression levels are not consistent. This paper summarizes the pertinent data on the inhibitory role of B7-H4 in antitumor immunity and its association with cancer progression and survival in human patients. The paper also discusses the clinical significance of investigating B7-H4 as potential markers for cancer diagnosis and prognosis, and as therapeutic targets.http://dx.doi.org/10.1155/2011/695834 |
| spellingShingle | Changjun He Haiquan Qiao Hongchi Jiang Xueying Sun The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and Survival Clinical and Developmental Immunology |
| title | The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and Survival |
| title_full | The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and Survival |
| title_fullStr | The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and Survival |
| title_full_unstemmed | The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and Survival |
| title_short | The Inhibitory Role of B7-H4 in Antitumor Immunity: Association with Cancer Progression and Survival |
| title_sort | inhibitory role of b7 h4 in antitumor immunity association with cancer progression and survival |
| url | http://dx.doi.org/10.1155/2011/695834 |
| work_keys_str_mv | AT changjunhe theinhibitoryroleofb7h4inantitumorimmunityassociationwithcancerprogressionandsurvival AT haiquanqiao theinhibitoryroleofb7h4inantitumorimmunityassociationwithcancerprogressionandsurvival AT hongchijiang theinhibitoryroleofb7h4inantitumorimmunityassociationwithcancerprogressionandsurvival AT xueyingsun theinhibitoryroleofb7h4inantitumorimmunityassociationwithcancerprogressionandsurvival AT changjunhe inhibitoryroleofb7h4inantitumorimmunityassociationwithcancerprogressionandsurvival AT haiquanqiao inhibitoryroleofb7h4inantitumorimmunityassociationwithcancerprogressionandsurvival AT hongchijiang inhibitoryroleofb7h4inantitumorimmunityassociationwithcancerprogressionandsurvival AT xueyingsun inhibitoryroleofb7h4inantitumorimmunityassociationwithcancerprogressionandsurvival |