Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats
Histone deacetylase inhibitors (HDACIs), which interfere with the epigenetic process of histone acetylation, have shown analgesic effects in animal models of persistent pain. The HDAC family comprises 18 genes; however, the different effects of distinct classes of HDACIs on pain relief remain unclea...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2019/1648919 |
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| author | Yu Mao Jing Zhou Xuesheng Liu Erwei Gu Zhi Zhang Wenjuan Tao |
| author_facet | Yu Mao Jing Zhou Xuesheng Liu Erwei Gu Zhi Zhang Wenjuan Tao |
| author_sort | Yu Mao |
| collection | DOAJ |
| description | Histone deacetylase inhibitors (HDACIs), which interfere with the epigenetic process of histone acetylation, have shown analgesic effects in animal models of persistent pain. The HDAC family comprises 18 genes; however, the different effects of distinct classes of HDACIs on pain relief remain unclear. The aim of this study was to determine the efficacy of these HDACIs on attenuating thermal hyperalgesia in persistent inflammatory pain. Persistent inflammatory pain was induced by injecting Complete Freund’s Adjuvant (CFA) into the left hind paw of rats. Then, HDACIs targeting class I (entinostat (MS-275)) and class IIa (sodium butyrate, valproic acid (VPA), and 4-phenylbutyric acid (4-PBA)), or class II (suberoylanilide hydoxamic acid (SAHA), trichostatin A (TSA), and dacinostat (LAQ824)) were administered intraperitoneally once daily for 3 or 4 days. We found that the injection of SAHA once a day for 3 days significantly attenuated CFA-induced thermal hyperalgesia from day 4 and lasted 7 days. In comparison with SAHA, suppression of hyperalgesia by 4-PBA peaked on day 2, whereas that by MS-275 occurred on days 5 and 6. Fatigue was a serious side effect seen with MS-275. These findings will be beneficial for optimizing the selection of specific HDACIs in medical fields such as pain medicine and neuropsychiatry. |
| format | Article |
| id | doaj-art-d97da4aeb5854c23832966382ef0084d |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-d97da4aeb5854c23832966382ef0084d2025-02-03T01:26:04ZengWileyPain Research and Management1203-67651918-15232019-01-01201910.1155/2019/16489191648919Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in RatsYu Mao0Jing Zhou1Xuesheng Liu2Erwei Gu3Zhi Zhang4Wenjuan Tao5Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui Province, ChinaDepartment of Head-neck and Breast Surgery, The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Cancer Hospital, Hefei, Anhui Province 233004, ChinaDepartment of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui Province, ChinaDepartment of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui Province, ChinaSchool of Life Sciences, University of Science and Technology of China, Huangshan Road 443, Hefei, Anhui Province, ChinaSchool of Basic Medical Sciences, Anhui Medical University, Meishan Road 81, Hefei, Anhui Province, ChinaHistone deacetylase inhibitors (HDACIs), which interfere with the epigenetic process of histone acetylation, have shown analgesic effects in animal models of persistent pain. The HDAC family comprises 18 genes; however, the different effects of distinct classes of HDACIs on pain relief remain unclear. The aim of this study was to determine the efficacy of these HDACIs on attenuating thermal hyperalgesia in persistent inflammatory pain. Persistent inflammatory pain was induced by injecting Complete Freund’s Adjuvant (CFA) into the left hind paw of rats. Then, HDACIs targeting class I (entinostat (MS-275)) and class IIa (sodium butyrate, valproic acid (VPA), and 4-phenylbutyric acid (4-PBA)), or class II (suberoylanilide hydoxamic acid (SAHA), trichostatin A (TSA), and dacinostat (LAQ824)) were administered intraperitoneally once daily for 3 or 4 days. We found that the injection of SAHA once a day for 3 days significantly attenuated CFA-induced thermal hyperalgesia from day 4 and lasted 7 days. In comparison with SAHA, suppression of hyperalgesia by 4-PBA peaked on day 2, whereas that by MS-275 occurred on days 5 and 6. Fatigue was a serious side effect seen with MS-275. These findings will be beneficial for optimizing the selection of specific HDACIs in medical fields such as pain medicine and neuropsychiatry.http://dx.doi.org/10.1155/2019/1648919 |
| spellingShingle | Yu Mao Jing Zhou Xuesheng Liu Erwei Gu Zhi Zhang Wenjuan Tao Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats Pain Research and Management |
| title | Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats |
| title_full | Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats |
| title_fullStr | Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats |
| title_full_unstemmed | Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats |
| title_short | Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats |
| title_sort | comparison of different histone deacetylase inhibitors in attenuating inflammatory pain in rats |
| url | http://dx.doi.org/10.1155/2019/1648919 |
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