Crosstalk between periodontitis and cardiovascular risk
Recent demographic developments resulted in an aged society with a rising disease burden of systemic and non-communicable diseases (NCDs). In cardiovascular disease (CVD), a NCD with high morbidity and mortality, recent preventive strategies include the investigation of comorbidities to reduce its s...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1469077/full |
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| author | Ulrike Schulze-Späte Ludwig Wurschi Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Frank Hölzle Rogerio B. Craveiro Michael Wolf Heidi Noels Heidi Noels Heidi Noels |
| author_facet | Ulrike Schulze-Späte Ludwig Wurschi Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Frank Hölzle Rogerio B. Craveiro Michael Wolf Heidi Noels Heidi Noels Heidi Noels |
| author_sort | Ulrike Schulze-Späte |
| collection | DOAJ |
| description | Recent demographic developments resulted in an aged society with a rising disease burden of systemic and non-communicable diseases (NCDs). In cardiovascular disease (CVD), a NCD with high morbidity and mortality, recent preventive strategies include the investigation of comorbidities to reduce its significant economic burden. Periodontal disease, an oral bacterial-induced inflammatory disease of tooth-supporting tissue, is regulated in its prevalence and severity by the individual host response to a dysbiotic oral microbiota. Clinically, both NCDs are highly associated; however, shared risk factors such as smoking, obesity, type II diabetes mellitus and chronic stress represent only an insufficient explanation for the multifaceted interactions of both disease entities. Specifically, the crosstalk between both diseases is not yet fully understood. This review summarizes current knowledge on the clinical association of periodontitis and CVD, and elaborates on how periodontitis-induced pathophysiological mechanisms in patients may contribute to increased cardiovascular risk with focus on atherosclerosis. Clinical implications as well as current and future therapy considerations are discussed. Overall, this review supports novel scientific endeavors aiming at improving the quality of life with a comprehensive and integrated approach to improve well-being of the aging populations worldwide. |
| format | Article |
| id | doaj-art-d97c6a0876284d8fbdf67c39d57a89a9 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-d97c6a0876284d8fbdf67c39d57a89a92025-08-20T02:20:44ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14690771469077Crosstalk between periodontitis and cardiovascular riskUlrike Schulze-Späte0Ludwig Wurschi1Emiel P. C. van der Vorst2Emiel P. C. van der Vorst3Emiel P. C. van der Vorst4Emiel P. C. van der Vorst5Frank Hölzle6Rogerio B. Craveiro7Michael Wolf8Heidi Noels9Heidi Noels10Heidi Noels11Section of Geriodontics, Department of Conservative Dentistry and Periodontics, University Hospital Jena, Jena, GermanySection of Geriodontics, Department of Conservative Dentistry and Periodontics, University Hospital Jena, Jena, GermanyInstitute for Molecular Cardiovascular Research (IMCAR), Uniklinik RWTH Aachen, RWTH Aachen University, Aachen, GermanyAachen-Maastricht Institute for Cardiorenal Research (AMICARE), Uniklinik RWTH Aachen, RWTH Aachen University, Aachen, GermanyInterdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, GermanyInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, Munich, GermanyDepartment of Oral and Maxillofacial Surgery, School of Medicine, Uniklinik RWTH Aachen, Aachen, GermanyDepartment of Orthodontics, Dental Clinic, Uniklinik RWTH Aachen, Aachen, GermanyDepartment of Orthodontics, Dental Clinic, Uniklinik RWTH Aachen, Aachen, GermanyInstitute for Molecular Cardiovascular Research (IMCAR), Uniklinik RWTH Aachen, RWTH Aachen University, Aachen, GermanyAachen-Maastricht Institute for Cardiorenal Research (AMICARE), Uniklinik RWTH Aachen, RWTH Aachen University, Aachen, GermanyBiochemistry Department, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, NetherlandsRecent demographic developments resulted in an aged society with a rising disease burden of systemic and non-communicable diseases (NCDs). In cardiovascular disease (CVD), a NCD with high morbidity and mortality, recent preventive strategies include the investigation of comorbidities to reduce its significant economic burden. Periodontal disease, an oral bacterial-induced inflammatory disease of tooth-supporting tissue, is regulated in its prevalence and severity by the individual host response to a dysbiotic oral microbiota. Clinically, both NCDs are highly associated; however, shared risk factors such as smoking, obesity, type II diabetes mellitus and chronic stress represent only an insufficient explanation for the multifaceted interactions of both disease entities. Specifically, the crosstalk between both diseases is not yet fully understood. This review summarizes current knowledge on the clinical association of periodontitis and CVD, and elaborates on how periodontitis-induced pathophysiological mechanisms in patients may contribute to increased cardiovascular risk with focus on atherosclerosis. Clinical implications as well as current and future therapy considerations are discussed. Overall, this review supports novel scientific endeavors aiming at improving the quality of life with a comprehensive and integrated approach to improve well-being of the aging populations worldwide.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1469077/fullperiodontitiscardiovascular diseaseinnate immunityinflammationdysbiosis |
| spellingShingle | Ulrike Schulze-Späte Ludwig Wurschi Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Frank Hölzle Rogerio B. Craveiro Michael Wolf Heidi Noels Heidi Noels Heidi Noels Crosstalk between periodontitis and cardiovascular risk Frontiers in Immunology periodontitis cardiovascular disease innate immunity inflammation dysbiosis |
| title | Crosstalk between periodontitis and cardiovascular risk |
| title_full | Crosstalk between periodontitis and cardiovascular risk |
| title_fullStr | Crosstalk between periodontitis and cardiovascular risk |
| title_full_unstemmed | Crosstalk between periodontitis and cardiovascular risk |
| title_short | Crosstalk between periodontitis and cardiovascular risk |
| title_sort | crosstalk between periodontitis and cardiovascular risk |
| topic | periodontitis cardiovascular disease innate immunity inflammation dysbiosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1469077/full |
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