Untargeted metabolomics revealed urinary metabolic pattern for discriminating prostate cancer from benign prostatic hyperplasia in Chinese participants
IntroductionPrecise screening and discriminating of prostatic hyperplasia (PH) could avoid unnecessary biopsy and overdiagnosis. However, the metabolic pattern of patients with prostatic hyperplasia in Chinese population is rarely reported.MethodsUrine samples of Chinese participants with prostate c...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1604169/full |
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| author | Chenye Tang Xiao Guo Qian Zou Xinghao Wang Jian Sheng Dan Shen Chun Sun Shuo Li Ruilin Shen |
| author_facet | Chenye Tang Xiao Guo Qian Zou Xinghao Wang Jian Sheng Dan Shen Chun Sun Shuo Li Ruilin Shen |
| author_sort | Chenye Tang |
| collection | DOAJ |
| description | IntroductionPrecise screening and discriminating of prostatic hyperplasia (PH) could avoid unnecessary biopsy and overdiagnosis. However, the metabolic pattern of patients with prostatic hyperplasia in Chinese population is rarely reported.MethodsUrine samples of Chinese participants with prostate cancer (PCa), benign prostatic hyperplasia (BPH) and non-prostate diseases (NPD) were detected with four ultra-performance liquid chromatography/tandem mass spectrometric (UPLC-MS/MS) methods to profile the metabolic disturbance.ResultsIn patients with PH, the most significant dysregulation was observed in metabolites categorized as lipid or amino acid, especially those involved in histidine metabolism, purine metabolism, tryptophan metabolism and tyrosine metabolism. For discrimination BPH from PCa, apart from previously reported metabolites related to phospholipid metabolism or tryptophan metabolism, metabolites of dipeptides and androgenic steroids, such as leucylhydroxyproline and etiocholanolone glucuronide, also exhibited potential to discriminate PCa from BPH.ConclusionThis study conducts precise detection of urinary metabolomic pattern for patients with benign prostatic hyperplasia or prostate cancer, and could inform their potential application as discriminant biomarkers. |
| format | Article |
| id | doaj-art-d9779d3debf04e42b9b24cd0bfb1b070 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-d9779d3debf04e42b9b24cd0bfb1b0702025-08-20T03:32:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.16041691604169Untargeted metabolomics revealed urinary metabolic pattern for discriminating prostate cancer from benign prostatic hyperplasia in Chinese participantsChenye Tang0Xiao Guo1Qian Zou2Xinghao Wang3Jian Sheng4Dan Shen5Chun Sun6Shuo Li7Ruilin Shen8Department of Urology, The Second Hospital of Jiaxing, Jiaxing, Zhejiang, ChinaDepartment of Urology, The Second Hospital of Jiaxing, Jiaxing, Zhejiang, ChinaDepartment of Urology, The Second Hospital of Jiaxing, Jiaxing, Zhejiang, ChinaJiaxing University Master Degree Cultivation Base, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Science and Education, The Second Hospital of Jiaxing, Jiaxing, Zhejiang, ChinaZhejiang Key Laboratory of Digital Technology in Medical Diagnostics, Dian Diagnostics Group Co., Ltd., Hangzhou, Zhejiang, ChinaDepartment of Urology, The Second Hospital of Jiaxing, Jiaxing, Zhejiang, ChinaZhejiang Key Laboratory of Digital Technology in Medical Diagnostics, Dian Diagnostics Group Co., Ltd., Hangzhou, Zhejiang, ChinaDepartment of Urology, The Second Hospital of Jiaxing, Jiaxing, Zhejiang, ChinaIntroductionPrecise screening and discriminating of prostatic hyperplasia (PH) could avoid unnecessary biopsy and overdiagnosis. However, the metabolic pattern of patients with prostatic hyperplasia in Chinese population is rarely reported.MethodsUrine samples of Chinese participants with prostate cancer (PCa), benign prostatic hyperplasia (BPH) and non-prostate diseases (NPD) were detected with four ultra-performance liquid chromatography/tandem mass spectrometric (UPLC-MS/MS) methods to profile the metabolic disturbance.ResultsIn patients with PH, the most significant dysregulation was observed in metabolites categorized as lipid or amino acid, especially those involved in histidine metabolism, purine metabolism, tryptophan metabolism and tyrosine metabolism. For discrimination BPH from PCa, apart from previously reported metabolites related to phospholipid metabolism or tryptophan metabolism, metabolites of dipeptides and androgenic steroids, such as leucylhydroxyproline and etiocholanolone glucuronide, also exhibited potential to discriminate PCa from BPH.ConclusionThis study conducts precise detection of urinary metabolomic pattern for patients with benign prostatic hyperplasia or prostate cancer, and could inform their potential application as discriminant biomarkers.https://www.frontiersin.org/articles/10.3389/fonc.2025.1604169/fullprostatic hyperplasiaprostate cancerurinary metabolomicsdiscriminant biomarkersuntargeted metabolomics |
| spellingShingle | Chenye Tang Xiao Guo Qian Zou Xinghao Wang Jian Sheng Dan Shen Chun Sun Shuo Li Ruilin Shen Untargeted metabolomics revealed urinary metabolic pattern for discriminating prostate cancer from benign prostatic hyperplasia in Chinese participants Frontiers in Oncology prostatic hyperplasia prostate cancer urinary metabolomics discriminant biomarkers untargeted metabolomics |
| title | Untargeted metabolomics revealed urinary metabolic pattern for discriminating prostate cancer from benign prostatic hyperplasia in Chinese participants |
| title_full | Untargeted metabolomics revealed urinary metabolic pattern for discriminating prostate cancer from benign prostatic hyperplasia in Chinese participants |
| title_fullStr | Untargeted metabolomics revealed urinary metabolic pattern for discriminating prostate cancer from benign prostatic hyperplasia in Chinese participants |
| title_full_unstemmed | Untargeted metabolomics revealed urinary metabolic pattern for discriminating prostate cancer from benign prostatic hyperplasia in Chinese participants |
| title_short | Untargeted metabolomics revealed urinary metabolic pattern for discriminating prostate cancer from benign prostatic hyperplasia in Chinese participants |
| title_sort | untargeted metabolomics revealed urinary metabolic pattern for discriminating prostate cancer from benign prostatic hyperplasia in chinese participants |
| topic | prostatic hyperplasia prostate cancer urinary metabolomics discriminant biomarkers untargeted metabolomics |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1604169/full |
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