Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia
Myelodysplastic syndrome (MDS) is cytogenetically heterogeneous and retains variable risk for acute myeloid leukemia transformation. Though not yet fully understood, there is an association between genetic abnormalities and defects in gene expression. The functional role for infrequent cytogenetic a...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2017/5404131 |
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| _version_ | 1832556413160783872 |
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| author | Aristides Armas Chen Chen Martha Mims Gustavo Rivero |
| author_facet | Aristides Armas Chen Chen Martha Mims Gustavo Rivero |
| author_sort | Aristides Armas |
| collection | DOAJ |
| description | Myelodysplastic syndrome (MDS) is cytogenetically heterogeneous and retains variable risk for acute myeloid leukemia transformation. Though not yet fully understood, there is an association between genetic abnormalities and defects in gene expression. The functional role for infrequent cytogenetic alteration remains unclear. An uncommon chromosomic abnormality is the presence of the Philadelphia (Ph) chromosome. Here, we report a patient with Ph+ MDS treated with low dose Dasatinib who achieved hematologic response for 7 months. In addition, we also examined the English literature on all de novo Ph + MDS cases between 1996 and 2015 to gain insight into clinical features and outcome. |
| format | Article |
| id | doaj-art-d9753f174685483d9ba3dd44acfb8c97 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-d9753f174685483d9ba3dd44acfb8c972025-02-03T05:45:35ZengWileyCase Reports in Hematology2090-65602090-65792017-01-01201710.1155/2017/54041315404131Uncovering Clinical Features of De Novo Philadelphia Positive MyelodysplasiaAristides Armas0Chen Chen1Martha Mims2Gustavo Rivero3Baylor St. Luke’s Medical Center, Houston, TX 77030, USABaylor College of Medicine, Section of Hematology and Oncology, 1 Baylor Plaza, Houston, TX 77030, USABaylor St. Luke’s Medical Center, Houston, TX 77030, USABaylor St. Luke’s Medical Center, Houston, TX 77030, USAMyelodysplastic syndrome (MDS) is cytogenetically heterogeneous and retains variable risk for acute myeloid leukemia transformation. Though not yet fully understood, there is an association between genetic abnormalities and defects in gene expression. The functional role for infrequent cytogenetic alteration remains unclear. An uncommon chromosomic abnormality is the presence of the Philadelphia (Ph) chromosome. Here, we report a patient with Ph+ MDS treated with low dose Dasatinib who achieved hematologic response for 7 months. In addition, we also examined the English literature on all de novo Ph + MDS cases between 1996 and 2015 to gain insight into clinical features and outcome.http://dx.doi.org/10.1155/2017/5404131 |
| spellingShingle | Aristides Armas Chen Chen Martha Mims Gustavo Rivero Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia Case Reports in Hematology |
| title | Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia |
| title_full | Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia |
| title_fullStr | Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia |
| title_full_unstemmed | Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia |
| title_short | Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia |
| title_sort | uncovering clinical features of de novo philadelphia positive myelodysplasia |
| url | http://dx.doi.org/10.1155/2017/5404131 |
| work_keys_str_mv | AT aristidesarmas uncoveringclinicalfeaturesofdenovophiladelphiapositivemyelodysplasia AT chenchen uncoveringclinicalfeaturesofdenovophiladelphiapositivemyelodysplasia AT marthamims uncoveringclinicalfeaturesofdenovophiladelphiapositivemyelodysplasia AT gustavorivero uncoveringclinicalfeaturesofdenovophiladelphiapositivemyelodysplasia |