Xuetongsu attenuates synovial inflammation in rheumatoid arthritis by inhibiting the IL-23/IL-17/NF-κB inflammatory axis

Xuetongsu attenuates synovial inflammation in rheumatoid arthritis by inhibiting the IL-23/IL-17/NF-κB inflammatory axis

IntroductionPersistent synovial hyperplasia, a hallmark of rheumatoid arthritis (RA), can lead to joint deformities. During the pathogenesis of RA, the expression of IL-23 promotes Th17 cell proliferation and IL-17 production, which in turn upregulates TNF-α, IL-1β, and RANKL in RA fibroblast-like s...

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Main Authors: Yuxin Chen, Yasi Deng, Hao Zheng, Bin Li, Yupei Yang, Juan Huang, Hanwen Yuan, Mengyun Wang, Wei Wang, Huanghe Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
rheumatoid arthritis
Xuetongsu
synovial inflammation
IL-23
IL-23/IL-17/NF-κB inflammatory signaling axis
RAFLS cell
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1615519/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1615519/full

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