Modulation of gut microbiota, up-regulation of ZO-1, and promotion of metabolism as therapeutic mechanisms of indole-3-carbinol against obesity in mice

Modulation of gut microbiota, up-regulation of ZO-1, and promotion of metabolism as therapeutic mechanisms of indole-3-carbinol against obesity in mice

BackgroundIndole-3-carbinol (I3C) is a compound derived from Cruciferous vegetables. We aim to ascertain whether I3C mediates the relations between mouse gut microbiota, intestinal barrier function, and metabolism to treat obesity in mice.MethodsThe experimental analyses focused on the changes in li...

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Bibliographic Details
Main Authors: XuWen Mao, Guliruoyi Paerhati, Yuche Wu, Lu Feng Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
indole-3-carbinol
gut microantha biota
obesity
serum metabolomics
ZO-1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1499142/full
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