Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo.

Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo.

Peripheral leukocytes can exacerbate brain damage by release of cytotoxic mediators that disrupt blood-brain barrier (BBB) function. One of the oxidants released by activated leukocytes is hypochlorous acid (HOCl) formed via the myeloperoxidase (MPO)-H2O2-Cl(-) system. In the present study we examin...

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Main Authors: Andreas Üllen, Evelin Singewald, Viktoria Konya, Günter Fauler, Helga Reicher, Christoph Nusshold, Astrid Hammer, Dagmar Kratky, Akos Heinemann, Peter Holzer, Ernst Malle, Wolfgang Sattler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0064034&type=printable
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