The prognostic value of the 8th American Joint Committee on cancer anatomic and prognostic stage groups for penile cancer: A multicenter collaboration study
Objective: The aim of this study was to investigate the value of the 8th American Joint Committee on Cancer (AJCC) anatomic and prognostic stage groups for penile cancer patients and explore whether there is room for improvement. Methods: The clinical and histopathologic data from 16 centers between...
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Elsevier
2025-01-01
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| Series: | Asian Journal of Urology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388224001176 |
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| author | Xueying Li Yepeng Guo Antonio Augusto Ornellas Jiun-Hung Geng Yonghong Li Wayne Lam Yabing Cao Zhuowei Liu Hui Han Fangjian Zhou Zaishang Li |
| author_facet | Xueying Li Yepeng Guo Antonio Augusto Ornellas Jiun-Hung Geng Yonghong Li Wayne Lam Yabing Cao Zhuowei Liu Hui Han Fangjian Zhou Zaishang Li |
| author_sort | Xueying Li |
| collection | DOAJ |
| description | Objective: The aim of this study was to investigate the value of the 8th American Joint Committee on Cancer (AJCC) anatomic and prognostic stage groups for penile cancer patients and explore whether there is room for improvement. Methods: The clinical and histopathologic data from 16 centers between January 2000 and December 2021 were assessed according to the 8th AJCC anatomic and prognostic stage groups. Kaplan–Meier plots were used to estimate the disease-specific survival (DSS) of the patients. The accuracy of the staging systems was investigated using the Harrell's concordance index (C-index). Results: According to the 8th AJCC anatomic and prognostic stage groups, the 5-year DSS rates for patients with stages 0is/a, I, IIA, IIB, IIIA, IIIB, and IV disease were 100%, 99%, 86%, 81%, 66%, 34%, and 23%, respectively (p0is/a–I=0.8, pI–IIA<0.001, pIIA–IIB=0.5, pIIB–IIIA<0.001, pIIIA–IIIB<0.001, pIIIB–IV=0.004, and pTotal<0.001). According to the modified model 1 system, the 5-year DSS rates without survivorship overlap for patients with stages 0is/a, I, II, IIIA, IIIB, and IV disease were 100%, 99%, 88%, 66%, 34%, and 23%, respectively (p0is/a–I=0.8, pI–II<0.001, pII–IIIA=0.002, pIIIA–IIIB<0.001, pIIIB–IV=0.004, and pTotal<0.001). Similarly, according to the modified model 2 system, the 5-year DSS rates without survivorship overlap for patients with stages 0is/a, I, II, IIIA, IIIB, and IV disease were 100%, 99%, 86%, 66%, 34%, and 23%, respectively (p0is/a–I=0.8, pI–II<0.001, pII–IIIA=0.008, pIIIA–IIIB<0.001, pIIIB–IV=0.004, and pTotal<0.001). The C-index scores of the simple modified staging systems were not inferior to those of the AJCC anatomic and prognostic stage groups. These results were confirmed by the bootstrap internal validation. Conclusion: There is still room for improvement about the 8th AJCC anatomic and prognostic stage groups. The improved models, which are more concise and convenient, have similar prediction accuracy. |
| format | Article |
| id | doaj-art-d94f7abea6af4a59b2a7bfdd332fb982 |
| institution | Kabale University |
| issn | 2214-3882 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Asian Journal of Urology |
| spelling | doaj-art-d94f7abea6af4a59b2a7bfdd332fb9822025-01-30T05:14:17ZengElsevierAsian Journal of Urology2214-38822025-01-01121100105The prognostic value of the 8th American Joint Committee on cancer anatomic and prognostic stage groups for penile cancer: A multicenter collaboration studyXueying Li0Yepeng Guo1Antonio Augusto Ornellas2Jiun-Hung Geng3Yonghong Li4Wayne Lam5Yabing Cao6Zhuowei Liu7Hui Han8Fangjian Zhou9Zaishang Li10Department of Oncology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDepartment of Urology, Shenzhen People's Hospital, The Second Clinic Medical College of Jinan University, Shenzhen, China; Department of Urology, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China; Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital, Shenzhen, ChinaDepartment of Urology, Brazilian National Cancer Institute, Rio de Janeiro, Brazil; Department of Urology, Hospital Mario Kröeff, Rio de Janeiro, BrazilDepartment of Urology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ChinaDepartment of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in South China, Guangzhou, China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, ChinaDivision of Urology, Department of Surgery, Queen Mary's Hospital, The University of Hong Kong, Hong Kong, ChinaDepartment of Oncology, Hospital Kiang Wu, Macao, ChinaDepartment of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in South China, Guangzhou, China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, ChinaDepartment of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in South China, Guangzhou, China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, China; Corresponding author. Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in South China, Guangzhou, China; Collaborative Innovation Center of Cancer Medicine, Guangzhou, China; Corresponding author. Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.Department of Urology, Shenzhen People's Hospital, The Second Clinic Medical College of Jinan University, Shenzhen, China; Department of Urology, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China; Shenzhen Clinical Research Center for Geriatrics, Shenzhen People's Hospital, Shenzhen, China; Corresponding author. Department of Urology, Shenzhen People's Hospital, Shenzhen, China.Objective: The aim of this study was to investigate the value of the 8th American Joint Committee on Cancer (AJCC) anatomic and prognostic stage groups for penile cancer patients and explore whether there is room for improvement. Methods: The clinical and histopathologic data from 16 centers between January 2000 and December 2021 were assessed according to the 8th AJCC anatomic and prognostic stage groups. Kaplan–Meier plots were used to estimate the disease-specific survival (DSS) of the patients. The accuracy of the staging systems was investigated using the Harrell's concordance index (C-index). Results: According to the 8th AJCC anatomic and prognostic stage groups, the 5-year DSS rates for patients with stages 0is/a, I, IIA, IIB, IIIA, IIIB, and IV disease were 100%, 99%, 86%, 81%, 66%, 34%, and 23%, respectively (p0is/a–I=0.8, pI–IIA<0.001, pIIA–IIB=0.5, pIIB–IIIA<0.001, pIIIA–IIIB<0.001, pIIIB–IV=0.004, and pTotal<0.001). According to the modified model 1 system, the 5-year DSS rates without survivorship overlap for patients with stages 0is/a, I, II, IIIA, IIIB, and IV disease were 100%, 99%, 88%, 66%, 34%, and 23%, respectively (p0is/a–I=0.8, pI–II<0.001, pII–IIIA=0.002, pIIIA–IIIB<0.001, pIIIB–IV=0.004, and pTotal<0.001). Similarly, according to the modified model 2 system, the 5-year DSS rates without survivorship overlap for patients with stages 0is/a, I, II, IIIA, IIIB, and IV disease were 100%, 99%, 86%, 66%, 34%, and 23%, respectively (p0is/a–I=0.8, pI–II<0.001, pII–IIIA=0.008, pIIIA–IIIB<0.001, pIIIB–IV=0.004, and pTotal<0.001). The C-index scores of the simple modified staging systems were not inferior to those of the AJCC anatomic and prognostic stage groups. These results were confirmed by the bootstrap internal validation. Conclusion: There is still room for improvement about the 8th AJCC anatomic and prognostic stage groups. The improved models, which are more concise and convenient, have similar prediction accuracy.http://www.sciencedirect.com/science/article/pii/S2214388224001176Penile cancerPrognosisTumor-node-metastasisSurvivalStage |
| spellingShingle | Xueying Li Yepeng Guo Antonio Augusto Ornellas Jiun-Hung Geng Yonghong Li Wayne Lam Yabing Cao Zhuowei Liu Hui Han Fangjian Zhou Zaishang Li The prognostic value of the 8th American Joint Committee on cancer anatomic and prognostic stage groups for penile cancer: A multicenter collaboration study Asian Journal of Urology Penile cancer Prognosis Tumor-node-metastasis Survival Stage |
| title | The prognostic value of the 8th American Joint Committee on cancer anatomic and prognostic stage groups for penile cancer: A multicenter collaboration study |
| title_full | The prognostic value of the 8th American Joint Committee on cancer anatomic and prognostic stage groups for penile cancer: A multicenter collaboration study |
| title_fullStr | The prognostic value of the 8th American Joint Committee on cancer anatomic and prognostic stage groups for penile cancer: A multicenter collaboration study |
| title_full_unstemmed | The prognostic value of the 8th American Joint Committee on cancer anatomic and prognostic stage groups for penile cancer: A multicenter collaboration study |
| title_short | The prognostic value of the 8th American Joint Committee on cancer anatomic and prognostic stage groups for penile cancer: A multicenter collaboration study |
| title_sort | prognostic value of the 8th american joint committee on cancer anatomic and prognostic stage groups for penile cancer a multicenter collaboration study |
| topic | Penile cancer Prognosis Tumor-node-metastasis Survival Stage |
| url | http://www.sciencedirect.com/science/article/pii/S2214388224001176 |
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