The R18 Polyarginine Peptide Is More Effective Than the TAT-NR2B9c (NA-1) Peptide When Administered 60 Minutes after Permanent Middle Cerebral Artery Occlusion in the Rat

The R18 Polyarginine Peptide Is More Effective Than the TAT-NR2B9c (NA-1) Peptide When Administered 60 Minutes after Permanent Middle Cerebral Artery Occlusion in the Rat

We examined the dose responsiveness of polyarginine R18 (100, 300, and 1000 nmol/kg) when administered 60 minutes after permanent middle cerebral artery occlusion (MCAO). The TAT-NR2B9c peptide, which is known to be neuroprotective in rodent and nonhuman primate stroke models, served as a positive c...

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Bibliographic Details
Main Authors: D. Milani, N. W. Knuckey, R. S. Anderton, J. L. Cross, B. P. Meloni
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Stroke Research and Treatment
Online Access:http://dx.doi.org/10.1155/2016/2372710
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