Transmission of HIV and HCV within Former Soviet Union Countries
Background. Following the collapse of the Union of Soviet Socialist Republic (USSR) in 1991, trans-border mobility increased within the former Soviet Union (FSU) countries. In addition, drug-trafficking and injection drug use began to rise, leading to the propagation and transmission of blood-borne...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2020/9701920 |
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| author | Lazzat Aibekova Aizada Bexeitova Arailym Aldabergenova Gonzalo Hortelano Zhangwen Ge Feng Yi Yiming Shao Jack DeHovitz Sten H. Vermund Syed Ali |
| author_facet | Lazzat Aibekova Aizada Bexeitova Arailym Aldabergenova Gonzalo Hortelano Zhangwen Ge Feng Yi Yiming Shao Jack DeHovitz Sten H. Vermund Syed Ali |
| author_sort | Lazzat Aibekova |
| collection | DOAJ |
| description | Background. Following the collapse of the Union of Soviet Socialist Republic (USSR) in 1991, trans-border mobility increased within the former Soviet Union (FSU) countries. In addition, drug-trafficking and injection drug use began to rise, leading to the propagation and transmission of blood-borne infections within and across the FSU countries. To examine the transmission of blood-borne infections within this region, we analyzed the phylogenetic relationship of publically available sequences of two blood-borne viruses, hepatitis C virus (HCV) and human immunodeficiency virus (HIV), from FSU countries. Methods. We analysed 614 and 295 NS5B sequences from HCV genotypes 1b and 3a, respectively, from 9 FSU countries. From 13 FSU countries, we analysed 347 HIV gag and 1282 HIV env sequences. To examine transmission networks and the origins of infection, respectively, phylogenetic and Bayesian analyses were performed. Results. Our analysis shows intermixing of HCV and HIV sequences, suggesting transmission of these viruses both within and across FSU countries. We show involvement of three major populations in transmission: injection drug user, heterosexual, and trans-border migrants. Conclusion. This study highlights the need to focus harm reduction efforts toward controlling transmission of blood-borne infections among the abovementioned high-risk populations in the FSU countries. |
| format | Article |
| id | doaj-art-d93484f9c3de4a2abb0d8681073a7e81 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-d93484f9c3de4a2abb0d8681073a7e812025-02-03T01:27:59ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972020-01-01202010.1155/2020/97019209701920Transmission of HIV and HCV within Former Soviet Union CountriesLazzat Aibekova0Aizada Bexeitova1Arailym Aldabergenova2Gonzalo Hortelano3Zhangwen Ge4Feng Yi5Yiming Shao6Jack DeHovitz7Sten H. Vermund8Syed Ali9Department of Biology, School of Science and Humanities, Nazarbayev University, Astana, KazakhstanDepartment of Biology, School of Science and Humanities, Nazarbayev University, Astana, KazakhstanDepartment of Biology, School of Science and Humanities, Nazarbayev University, Astana, KazakhstanDepartment of Biology, School of Science and Humanities, Nazarbayev University, Astana, KazakhstanState Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaState Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaState Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaDepartment of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USAYale School of Public Health, New Haven, CT, USADepartment of Biomedical Sciences, Nazarbayev School of Medicine, Nazarbayev University, Astana, KazakhstanBackground. Following the collapse of the Union of Soviet Socialist Republic (USSR) in 1991, trans-border mobility increased within the former Soviet Union (FSU) countries. In addition, drug-trafficking and injection drug use began to rise, leading to the propagation and transmission of blood-borne infections within and across the FSU countries. To examine the transmission of blood-borne infections within this region, we analyzed the phylogenetic relationship of publically available sequences of two blood-borne viruses, hepatitis C virus (HCV) and human immunodeficiency virus (HIV), from FSU countries. Methods. We analysed 614 and 295 NS5B sequences from HCV genotypes 1b and 3a, respectively, from 9 FSU countries. From 13 FSU countries, we analysed 347 HIV gag and 1282 HIV env sequences. To examine transmission networks and the origins of infection, respectively, phylogenetic and Bayesian analyses were performed. Results. Our analysis shows intermixing of HCV and HIV sequences, suggesting transmission of these viruses both within and across FSU countries. We show involvement of three major populations in transmission: injection drug user, heterosexual, and trans-border migrants. Conclusion. This study highlights the need to focus harm reduction efforts toward controlling transmission of blood-borne infections among the abovementioned high-risk populations in the FSU countries.http://dx.doi.org/10.1155/2020/9701920 |
| spellingShingle | Lazzat Aibekova Aizada Bexeitova Arailym Aldabergenova Gonzalo Hortelano Zhangwen Ge Feng Yi Yiming Shao Jack DeHovitz Sten H. Vermund Syed Ali Transmission of HIV and HCV within Former Soviet Union Countries Canadian Journal of Gastroenterology and Hepatology |
| title | Transmission of HIV and HCV within Former Soviet Union Countries |
| title_full | Transmission of HIV and HCV within Former Soviet Union Countries |
| title_fullStr | Transmission of HIV and HCV within Former Soviet Union Countries |
| title_full_unstemmed | Transmission of HIV and HCV within Former Soviet Union Countries |
| title_short | Transmission of HIV and HCV within Former Soviet Union Countries |
| title_sort | transmission of hiv and hcv within former soviet union countries |
| url | http://dx.doi.org/10.1155/2020/9701920 |
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