A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy

A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy

Summary: Colorectal cancer (CRC) is increasing globally, making identification of preventative measures necessary. Transplantation of the microbiota from CRC and non-CRC patients into mice demonstrates that non-diseased individuals possess organisms that reduce tumor formation and highlights Bacteri...

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Main Authors: Allison M. Weis, Kaylyn M. Bauer, William W. Tang, Emmanuel Stephen-Victor, Rickesha Bell, D. Garrett Brown, H. Atakan Ekiz, Van Tran, Kendra A. Klag, Eric A. Swanson, Logan Barrios, Morgan Harwood, Jennifer H. Hill, Kyla S. Ost, Biljana Gigic, Martin Schneider, Jennifer Ose, Sheetal Hardikar, Adetunji T. Toriola, David Shibata, Christopher I. Li, Jane C. Figueiredo, Doratha A. Byrd, Erin M. Siegel, Kathleen Arnolds, Catherine Lozupone, Cornelia M. Ulrich, Ryan M. O’Connell, W. Zac Stephens, June L. Round
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Cell Reports
Subjects:
CP: Microbiology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500943X
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