Socioeconomic characteristics and relapse-free and overall survival from childhood cancer – a nationwide study based on data from the Danish Childhood Cancer Registry
Background and purpose: Over the past decades, childhood cancer survival has increased substantially in Europe, including Denmark. However, families with fewer social resources may have benefitted less from these improvements. In this nationwide register-based study, we assessed associations between...
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Medical Journals Sweden
2025-01-01
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| Series: | Acta Oncologica |
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| Online Access: | https://medicaljournalssweden.se/actaoncologica/article/view/42131 |
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| author | Fie Stegenborg Mathilde Bek Charlotte Nilsson Line H. Pedersen Thomas Scheike Lisa Hjalgrim Friederike Erdmann Kjeld Schmiegelow Pernille Bidstrup Line Kenborg Jeanette Winther Hanne Larsen Susanne Dalton |
| author_facet | Fie Stegenborg Mathilde Bek Charlotte Nilsson Line H. Pedersen Thomas Scheike Lisa Hjalgrim Friederike Erdmann Kjeld Schmiegelow Pernille Bidstrup Line Kenborg Jeanette Winther Hanne Larsen Susanne Dalton |
| author_sort | Fie Stegenborg |
| collection | DOAJ |
| description | Background and purpose: Over the past decades, childhood cancer survival has increased substantially in Europe, including Denmark. However, families with fewer social resources may have benefitted less from these improvements. In this nationwide register-based study, we assessed associations between parental socioeconomic position (SEP) and 5-year relapse-free survival (RFS) and overall survival (OS) in childhood cancer patients.
Material and methods: All children aged <16 years diagnosed with cancer in Denmark between 1998 and 2017 were identified in the Danish Childhood Cancer Registry (N = 3245). Parents, with whom the children resided, were identified, and data on the parents’ education, cohabitation status, affiliation to work market, country of origin, and vital status of the children were obtained through individual-level linkage across Danish nationwide registries. Cox proportional hazards models were used to estimate the association between SEP indicators and 5-year RFS and OS.
Results and interpretation: Tendencies towards lower 5-year RFS and OS were observed among children whose parents were unemployed/not in workforce (RFS: HR [hazard ratio] = 1.14, 95% CI [confidence interval]: 0.90–1.45, OS: HR = 1.28, 95% CI: 0.95–1.71) or from non-Western countries (RFS: HR = 1.21 95% CI: 0.96–1.52, OS: HR = 1.44, 95% CI: 1.09–1.90). Results by diagnostic groups revealed particularly low OS for children with non-central nervous system tumors whose parents were from non-Western countries (HR = 1.92, 95% CI: 1.24–2.97). Targeted strategies are needed to promote social equity and ensure optimal diagnosis, care, and management of childhood cancer across social groups.
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| format | Article |
| id | doaj-art-d907f578b2b24caeaeaeedb0d69209a6 |
| institution | Kabale University |
| issn | 1651-226X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Oncologica |
| spelling | doaj-art-d907f578b2b24caeaeaeedb0d69209a62025-01-30T08:31:07ZengMedical Journals SwedenActa Oncologica1651-226X2025-01-016410.2340/1651-226X.2025.42131Socioeconomic characteristics and relapse-free and overall survival from childhood cancer – a nationwide study based on data from the Danish Childhood Cancer RegistryFie Stegenborg0https://orcid.org/0009-0006-9591-4500Mathilde Bek1Charlotte Nilsson2Line H. Pedersen3Thomas Scheike4Lisa Hjalgrim5Friederike Erdmann6Kjeld Schmiegelow7Pernille Bidstrup8Line Kenborg9Jeanette Winther10Hanne Larsen11Susanne Dalton12Cancer Survivorship, Danish Cancer Institute, Copenhagen, DenmarkCancer Survivorship, Danish Cancer Institute, Copenhagen, DenmarkSection of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkCancer Survivorship, Danish Cancer Institute, Copenhagen, DenmarkSection of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, RigshospitaletResearch group Etiology and Inequalities in Childhood Cancer, Division of Childhood Cancer Epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University Mainz, Germany; Department of Prevention and Evaluation, Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, GermanyDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, DenmarkPsychological Aspects of Cancer, Danish Cancer Institute, Danish Cancer Society, Copenhagen, Denmark; Department of Psychology, University of Copenhagen, DenmarkChildhood Cancer Research Group, Danish Cancer Institute, Copenhagen, DenmarkChildhood Cancer Research Group, Danish Cancer Institute, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University and Aarhus University Hospital, DenmarkDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, RigshospitaletCancer Survivorship, Danish Cancer Institute, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Denmark; Department of Clinical Oncology & Palliative Care, Zealand University Hospital, Naestved, DenmarkBackground and purpose: Over the past decades, childhood cancer survival has increased substantially in Europe, including Denmark. However, families with fewer social resources may have benefitted less from these improvements. In this nationwide register-based study, we assessed associations between parental socioeconomic position (SEP) and 5-year relapse-free survival (RFS) and overall survival (OS) in childhood cancer patients. Material and methods: All children aged <16 years diagnosed with cancer in Denmark between 1998 and 2017 were identified in the Danish Childhood Cancer Registry (N = 3245). Parents, with whom the children resided, were identified, and data on the parents’ education, cohabitation status, affiliation to work market, country of origin, and vital status of the children were obtained through individual-level linkage across Danish nationwide registries. Cox proportional hazards models were used to estimate the association between SEP indicators and 5-year RFS and OS. Results and interpretation: Tendencies towards lower 5-year RFS and OS were observed among children whose parents were unemployed/not in workforce (RFS: HR [hazard ratio] = 1.14, 95% CI [confidence interval]: 0.90–1.45, OS: HR = 1.28, 95% CI: 0.95–1.71) or from non-Western countries (RFS: HR = 1.21 95% CI: 0.96–1.52, OS: HR = 1.44, 95% CI: 1.09–1.90). Results by diagnostic groups revealed particularly low OS for children with non-central nervous system tumors whose parents were from non-Western countries (HR = 1.92, 95% CI: 1.24–2.97). Targeted strategies are needed to promote social equity and ensure optimal diagnosis, care, and management of childhood cancer across social groups. https://medicaljournalssweden.se/actaoncologica/article/view/42131Childhood cancerSocioeconomic positionSocial inequalityrelapseCancer survivalregister-based study |
| spellingShingle | Fie Stegenborg Mathilde Bek Charlotte Nilsson Line H. Pedersen Thomas Scheike Lisa Hjalgrim Friederike Erdmann Kjeld Schmiegelow Pernille Bidstrup Line Kenborg Jeanette Winther Hanne Larsen Susanne Dalton Socioeconomic characteristics and relapse-free and overall survival from childhood cancer – a nationwide study based on data from the Danish Childhood Cancer Registry Acta Oncologica Childhood cancer Socioeconomic position Social inequality relapse Cancer survival register-based study |
| title | Socioeconomic characteristics and relapse-free and overall survival from childhood cancer – a nationwide study based on data from the Danish Childhood Cancer Registry |
| title_full | Socioeconomic characteristics and relapse-free and overall survival from childhood cancer – a nationwide study based on data from the Danish Childhood Cancer Registry |
| title_fullStr | Socioeconomic characteristics and relapse-free and overall survival from childhood cancer – a nationwide study based on data from the Danish Childhood Cancer Registry |
| title_full_unstemmed | Socioeconomic characteristics and relapse-free and overall survival from childhood cancer – a nationwide study based on data from the Danish Childhood Cancer Registry |
| title_short | Socioeconomic characteristics and relapse-free and overall survival from childhood cancer – a nationwide study based on data from the Danish Childhood Cancer Registry |
| title_sort | socioeconomic characteristics and relapse free and overall survival from childhood cancer a nationwide study based on data from the danish childhood cancer registry |
| topic | Childhood cancer Socioeconomic position Social inequality relapse Cancer survival register-based study |
| url | https://medicaljournalssweden.se/actaoncologica/article/view/42131 |
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