The role of the early-life gut microbiome in childhood asthma
Asthma is a chronic disease affecting millions of children worldwide, and in severe cases requires hospitalization. The etiology of asthma is multifactorial, caused by both genetic and environmental factors. In recent years, the role of the early-life gut microbiome in relation to asthma has become...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2457489 |
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| author | Ulrika Boulund Jonathan Thorsen Urvish Trivedi Kaare Tranæs Jie Jiang Shiraz A. Shah Jakob Stokholm |
| author_facet | Ulrika Boulund Jonathan Thorsen Urvish Trivedi Kaare Tranæs Jie Jiang Shiraz A. Shah Jakob Stokholm |
| author_sort | Ulrika Boulund |
| collection | DOAJ |
| description | Asthma is a chronic disease affecting millions of children worldwide, and in severe cases requires hospitalization. The etiology of asthma is multifactorial, caused by both genetic and environmental factors. In recent years, the role of the early-life gut microbiome in relation to asthma has become apparent, supported by an increasing number of population studies, in vivo research, and intervention trials. Numerous early-life factors, which for decades have been associated with the risk of developing childhood asthma, are now being linked to the disease through alterations of the gut microbiome. These factors include cesarean birth, antibiotic use, breastfeeding, and having siblings or pets, among others. Association studies have highlighted several specific microbes that are altered in children developing asthma, but these can vary between studies and disease phenotype. This demonstrates the importance of the gut microbial ecosystem in asthma, and the necessity of well-designed studies to validate the underlying mechanisms and guide future clinical applications. In this review, we examine the current literature on the role of the gut microbiome in childhood asthma and identify research gaps to allow for future microbial-focused therapeutic applications in asthma. |
| format | Article |
| id | doaj-art-d9000b821d1f4e82be635900c70b7ae6 |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-d9000b821d1f4e82be635900c70b7ae62025-01-30T10:15:32ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2457489The role of the early-life gut microbiome in childhood asthmaUlrika Boulund0Jonathan Thorsen1Urvish Trivedi2Kaare Tranæs3Jie Jiang4Shiraz A. Shah5Jakob Stokholm6Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Herlev-Gentofte, Gentofte, DenmarkCopenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Herlev-Gentofte, Gentofte, DenmarkCopenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Herlev-Gentofte, Gentofte, DenmarkCopenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Herlev-Gentofte, Gentofte, DenmarkCopenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Herlev-Gentofte, Gentofte, DenmarkCopenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Herlev-Gentofte, Gentofte, DenmarkCopenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Herlev-Gentofte, Gentofte, DenmarkAsthma is a chronic disease affecting millions of children worldwide, and in severe cases requires hospitalization. The etiology of asthma is multifactorial, caused by both genetic and environmental factors. In recent years, the role of the early-life gut microbiome in relation to asthma has become apparent, supported by an increasing number of population studies, in vivo research, and intervention trials. Numerous early-life factors, which for decades have been associated with the risk of developing childhood asthma, are now being linked to the disease through alterations of the gut microbiome. These factors include cesarean birth, antibiotic use, breastfeeding, and having siblings or pets, among others. Association studies have highlighted several specific microbes that are altered in children developing asthma, but these can vary between studies and disease phenotype. This demonstrates the importance of the gut microbial ecosystem in asthma, and the necessity of well-designed studies to validate the underlying mechanisms and guide future clinical applications. In this review, we examine the current literature on the role of the gut microbiome in childhood asthma and identify research gaps to allow for future microbial-focused therapeutic applications in asthma.https://www.tandfonline.com/doi/10.1080/19490976.2025.2457489Childhood asthmagut microbiomeearly-lifevirome |
| spellingShingle | Ulrika Boulund Jonathan Thorsen Urvish Trivedi Kaare Tranæs Jie Jiang Shiraz A. Shah Jakob Stokholm The role of the early-life gut microbiome in childhood asthma Gut Microbes Childhood asthma gut microbiome early-life virome |
| title | The role of the early-life gut microbiome in childhood asthma |
| title_full | The role of the early-life gut microbiome in childhood asthma |
| title_fullStr | The role of the early-life gut microbiome in childhood asthma |
| title_full_unstemmed | The role of the early-life gut microbiome in childhood asthma |
| title_short | The role of the early-life gut microbiome in childhood asthma |
| title_sort | role of the early life gut microbiome in childhood asthma |
| topic | Childhood asthma gut microbiome early-life virome |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2025.2457489 |
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