STEAP3 promotes triple-negative breast cancer growth through the FGFR1-mediated activation of PI3K/AKT/mTOR signaling

STEAP3 promotes triple-negative breast cancer growth through the FGFR1-mediated activation of PI3K/AKT/mTOR signaling

Summary: Triple-negative breast cancer (TNBC) is a highly aggressive subtype with a poor prognosis and lacks effective targeted therapies. Six-transmembrane epithelial antigen of prostate 3(STEAP3) is specifically overexpressed in TNBC, but its precise role and molecular mechanisms remain unclear. H...

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Bibliographic Details
Main Authors: Lifang Yuan, Yuhan Bao, Junbao Liu, Ping Sun
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Cancer
Cell biology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225007874
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