Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice
The present study is aimed at testing the antidepressant--like effects and probable mechanisms of action of low molecular mass chondroitin sulfate (LMMCS) on depression induced by chronic unpredictable mild stress (CUMS) in mice. Four weeks of CUMS exposure resulted in depressive-like behavior, expr...
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| Format: | Article |
| Language: | English |
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Sciendo
2018-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2018-0028 |
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| author | Si Xiao-Ming Tian Yu-Hua Zhang Sha-Sha Gao Hua Liu Kun Jin Jing-Yu |
| author_facet | Si Xiao-Ming Tian Yu-Hua Zhang Sha-Sha Gao Hua Liu Kun Jin Jing-Yu |
| author_sort | Si Xiao-Ming |
| collection | DOAJ |
| description | The present study is aimed at testing the antidepressant--like effects and probable mechanisms of action of low molecular mass chondroitin sulfate (LMMCS) on depression induced by chronic unpredictable mild stress (CUMS) in mice. Four weeks of CUMS exposure resulted in depressive-like behavior, expressed by a significant decrease in the locomotor activity and sucrose consumption and increased immobility time in the forced swim test. Further, there was a significant reduction of 5-HT level in the hippocampus region of depressed mice. Treatment of mice for four weeks with LMMCS ameliorated significantly both the behavioral and biochemical changes induced by CUMS. These novel results suggest that LMMCS produces an antidepressant-like effect in mice subjected to CUMS, which might be related, at least in part, to the increase of 5-HT concentration in the hippocampus. |
| format | Article |
| id | doaj-art-d8fbfd9381b74541a554b7c8d2349ef5 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2018-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-d8fbfd9381b74541a554b7c8d2349ef52025-02-02T12:01:39ZengSciendoActa Pharmaceutica1846-95582018-09-0168336137110.2478/acph-2018-0028acph-2018-0028Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in miceSi Xiao-Ming0Tian Yu-Hua1Zhang Sha-Sha2Gao Hua3Liu Kun4Jin Jing-Yu5Department of Pharmacology School of Pharmacy, Qingdao University, Qingdao, 266021, ChinaDepartment of Pharmacology School of Pharmacy, Qingdao University, Qingdao, 266021, ChinaDepartment of Pharmacology School of Pharmacy, Qingdao University, Qingdao, 266021, ChinaDepartment of Medicinal Chemistry School of Pharmacy, Qingdao University, Qingdao, 266021, ChinaDepartment of Pharmaceutical Analysis, School of Pharmacy, Qingdao University, Qingdao, 266021, ChinaDepartment of Pharmacology School of Pharmacy, Qingdao University, Qingdao, 266021, ChinaThe present study is aimed at testing the antidepressant--like effects and probable mechanisms of action of low molecular mass chondroitin sulfate (LMMCS) on depression induced by chronic unpredictable mild stress (CUMS) in mice. Four weeks of CUMS exposure resulted in depressive-like behavior, expressed by a significant decrease in the locomotor activity and sucrose consumption and increased immobility time in the forced swim test. Further, there was a significant reduction of 5-HT level in the hippocampus region of depressed mice. Treatment of mice for four weeks with LMMCS ameliorated significantly both the behavioral and biochemical changes induced by CUMS. These novel results suggest that LMMCS produces an antidepressant-like effect in mice subjected to CUMS, which might be related, at least in part, to the increase of 5-HT concentration in the hippocampus.https://doi.org/10.2478/acph-2018-0028low molecular mass chondroitin sulfatechronic unpredictable mild stressdepressionmicehippocampus5-ht |
| spellingShingle | Si Xiao-Ming Tian Yu-Hua Zhang Sha-Sha Gao Hua Liu Kun Jin Jing-Yu Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice Acta Pharmaceutica low molecular mass chondroitin sulfate chronic unpredictable mild stress depression mice hippocampus 5-ht |
| title | Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice |
| title_full | Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice |
| title_fullStr | Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice |
| title_full_unstemmed | Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice |
| title_short | Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice |
| title_sort | low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress induced depression like behavior in mice |
| topic | low molecular mass chondroitin sulfate chronic unpredictable mild stress depression mice hippocampus 5-ht |
| url | https://doi.org/10.2478/acph-2018-0028 |
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