RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation

RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation

Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. Our study reveals that the RAS–p110α signalling pathway, known for its involvement in various biological processes and tumourigenesis, regulates two vital aspects of t...

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Main Authors: Alejandro Rosell, Agata Adelajda Krygowska, Marta Alcón Pérez, Cristina Cuesta, Mathieu-Benoit Voisin, Juan de Paz, Héctor Sanz-Fraile, Vinothini Rajeeve, Ana Carreras-González, Alberto Berral-González, Ottilie Swinyard, Enrique Gabandé-Rodríguez, Julian Downward, Jordi Alcaraz, Juan Anguita, Carmen García-Macías, Javier De Las Rivas, Pedro R Cutillas, Esther Castellano Sanchez
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
macrophages
inflammation
RAS–p110α
Online Access:https://elifesciences.org/articles/94590
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