Predicting prognosis using stroke-heart indicator: brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage
ObjectiveThis study aims to explore the correlation between brain natriuretic peptide (BNP) levels and prognosis in patients suffering from aneurysmal subarachnoid hemorrhage (aSAH).MethodsThis retrospective study included patients diagnosed with aneurysmal subarachnoid hemorrhage (aSAH) at Beijing...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1510235/full |
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| author | Jionghao Xue Jionghao Xue Fa Lin Fa Lin Minghao Liu Minghao Liu Wenxiong Song Wenxiong Song Runting Li Runting Li Yu Chen Yu Chen Jun Yang Jun Yang Heze Han Heze Han Yitong Jia Yitong Jia Xiaolin Chen Xiaolin Chen Rong Wang Rong Wang Yuanli Zhao |
| author_facet | Jionghao Xue Jionghao Xue Fa Lin Fa Lin Minghao Liu Minghao Liu Wenxiong Song Wenxiong Song Runting Li Runting Li Yu Chen Yu Chen Jun Yang Jun Yang Heze Han Heze Han Yitong Jia Yitong Jia Xiaolin Chen Xiaolin Chen Rong Wang Rong Wang Yuanli Zhao |
| author_sort | Jionghao Xue |
| collection | DOAJ |
| description | ObjectiveThis study aims to explore the correlation between brain natriuretic peptide (BNP) levels and prognosis in patients suffering from aneurysmal subarachnoid hemorrhage (aSAH).MethodsThis retrospective study included patients diagnosed with aneurysmal subarachnoid hemorrhage (aSAH) at Beijing Tiantan Hospital between January 2015 and September 2021. Plasma BNP levels were measured upon admission and log-transformed to reduce skewness. Elevated BNP was defined as lgBNP ≥1.79 (equivalent to BNP ≥62 pg./mL). The primary outcome was poor prognosis, defined as a modified Rankin Scale (mRS) score ≥ 3 at 90 days. Univariable and multivariable logistic regression analyses were conducted to examine the association between BNP levels and prognosis. Additionally, we assessed the potential impact of incorporating BNP into a predictive model for poor prognosis.ResultsThe statistical analysis encompassed a total of 932 patients. Among them, 171 individuals experienced unfavorable prognosis (mRS ≥3) during follow-up, and 444 patients had elevated BNP levels, defined as lgBNP ≥1.79. After accounting for confounding factors, elevated BNP levels remained a significant independent risk factor of a poor prognosis (p = 0.047, OR = 1.49, 95%CI = 1.01–2.20). Nevertheless, BNP’s predictive value alone might not warrant its inclusion in a prognostic model.ConclusionElevated BNP levels independently forecast unfavorable prognosis in patients with aSAH, even though the cutoff value is lower than the cardiology standards. Continuous monitoring and personalized hospitalization plans can be vital for these patients. |
| format | Article |
| id | doaj-art-d8e43d919e1c4a60882bdb8c8f4f6c32 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-d8e43d919e1c4a60882bdb8c8f4f6c322025-01-22T05:19:22ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011610.3389/fneur.2025.15102351510235Predicting prognosis using stroke-heart indicator: brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhageJionghao Xue0Jionghao Xue1Fa Lin2Fa Lin3Minghao Liu4Minghao Liu5Wenxiong Song6Wenxiong Song7Runting Li8Runting Li9Yu Chen10Yu Chen11Jun Yang12Jun Yang13Heze Han14Heze Han15Yitong Jia16Yitong Jia17Xiaolin Chen18Xiaolin Chen19Rong Wang20Rong Wang21Yuanli Zhao22Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Discases, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Discases, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Discases, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Discases, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Discases, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Discases, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Discases, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Discases, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Discases, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Discases, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Discases, Beijing, ChinaDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaObjectiveThis study aims to explore the correlation between brain natriuretic peptide (BNP) levels and prognosis in patients suffering from aneurysmal subarachnoid hemorrhage (aSAH).MethodsThis retrospective study included patients diagnosed with aneurysmal subarachnoid hemorrhage (aSAH) at Beijing Tiantan Hospital between January 2015 and September 2021. Plasma BNP levels were measured upon admission and log-transformed to reduce skewness. Elevated BNP was defined as lgBNP ≥1.79 (equivalent to BNP ≥62 pg./mL). The primary outcome was poor prognosis, defined as a modified Rankin Scale (mRS) score ≥ 3 at 90 days. Univariable and multivariable logistic regression analyses were conducted to examine the association between BNP levels and prognosis. Additionally, we assessed the potential impact of incorporating BNP into a predictive model for poor prognosis.ResultsThe statistical analysis encompassed a total of 932 patients. Among them, 171 individuals experienced unfavorable prognosis (mRS ≥3) during follow-up, and 444 patients had elevated BNP levels, defined as lgBNP ≥1.79. After accounting for confounding factors, elevated BNP levels remained a significant independent risk factor of a poor prognosis (p = 0.047, OR = 1.49, 95%CI = 1.01–2.20). Nevertheless, BNP’s predictive value alone might not warrant its inclusion in a prognostic model.ConclusionElevated BNP levels independently forecast unfavorable prognosis in patients with aSAH, even though the cutoff value is lower than the cardiology standards. Continuous monitoring and personalized hospitalization plans can be vital for these patients.https://www.frontiersin.org/articles/10.3389/fneur.2025.1510235/fullstroke heart diseaseASAHbnpretrospective studiesrisk factors |
| spellingShingle | Jionghao Xue Jionghao Xue Fa Lin Fa Lin Minghao Liu Minghao Liu Wenxiong Song Wenxiong Song Runting Li Runting Li Yu Chen Yu Chen Jun Yang Jun Yang Heze Han Heze Han Yitong Jia Yitong Jia Xiaolin Chen Xiaolin Chen Rong Wang Rong Wang Yuanli Zhao Predicting prognosis using stroke-heart indicator: brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage Frontiers in Neurology stroke heart disease ASAH bnp retrospective studies risk factors |
| title | Predicting prognosis using stroke-heart indicator: brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage |
| title_full | Predicting prognosis using stroke-heart indicator: brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage |
| title_fullStr | Predicting prognosis using stroke-heart indicator: brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage |
| title_full_unstemmed | Predicting prognosis using stroke-heart indicator: brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage |
| title_short | Predicting prognosis using stroke-heart indicator: brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage |
| title_sort | predicting prognosis using stroke heart indicator brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage |
| topic | stroke heart disease ASAH bnp retrospective studies risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1510235/full |
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