Interval Cancers in a Population-Based Screening Program for Colorectal Cancer in Catalonia, Spain
Objective. To analyze interval cancers among participants in a screening program for colorectal cancer (CRC) during four screening rounds. Methods. The study population consisted of participants of a fecal occult blood test-based screening program from February 2000 to September 2010, with a 30-mont...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/672410 |
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| author | M. Garcia X. Domènech C. Vidal E. Torné N. Milà G. Binefa L. Benito V. Moreno |
| author_facet | M. Garcia X. Domènech C. Vidal E. Torné N. Milà G. Binefa L. Benito V. Moreno |
| author_sort | M. Garcia |
| collection | DOAJ |
| description | Objective. To analyze interval cancers among participants in a screening program for colorectal cancer (CRC) during four screening rounds. Methods. The study population consisted of participants of a fecal occult blood test-based screening program from February 2000 to September 2010, with a 30-month follow-up (n = 30,480). We used hospital administration data to identify CRC. An interval cancer was defined as an invasive cancer diagnosed within 30 months of a negative screening result and before the next recommended examination. Gender, age, stage, and site distribution of interval cancers were compared with those in the screen-detected group. Results. Within the study period, 97 tumors were screen-detected and 74 tumors were diagnosed after a negative screening. In addition, 17 CRC (18.3%) were found after an inconclusive result and 2 cases were diagnosed within the surveillance interval (2.1%). There was an increase of interval cancers over the four rounds (from 32.4% to 46.0%). When compared with screen-detected cancers, interval cancers were found predominantly in the rectum (OR: 3.66; 95% CI: 1.51–8.88) and at more advanced stages (P=0.025). Conclusion. There are large numbers of cancer that are not detected through fecal occult blood test-based screening. The low sensitivity should be emphasized to ensure that individuals with symptoms are not falsely reassured. |
| format | Article |
| id | doaj-art-d8e001abb9e34e9ca157105974636a82 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-d8e001abb9e34e9ca157105974636a822025-02-03T05:51:57ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/672410672410Interval Cancers in a Population-Based Screening Program for Colorectal Cancer in Catalonia, SpainM. Garcia0X. Domènech1C. Vidal2E. Torné3N. Milà4G. Binefa5L. Benito6V. Moreno7Cancer Prevention and Control Program, Catalan Institute of Oncology, IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, SpainCancer Prevention and Control Program, Catalan Institute of Oncology, IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, SpainCancer Prevention and Control Program, Catalan Institute of Oncology, IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, SpainBarcelona Health Region, CatSalut, 08023 Barcelona, SpainCancer Prevention and Control Program, Catalan Institute of Oncology, IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, SpainCancer Prevention and Control Program, Catalan Institute of Oncology, IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, SpainCancer Prevention and Control Program, Catalan Institute of Oncology, IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, SpainCancer Prevention and Control Program, Catalan Institute of Oncology, IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, SpainObjective. To analyze interval cancers among participants in a screening program for colorectal cancer (CRC) during four screening rounds. Methods. The study population consisted of participants of a fecal occult blood test-based screening program from February 2000 to September 2010, with a 30-month follow-up (n = 30,480). We used hospital administration data to identify CRC. An interval cancer was defined as an invasive cancer diagnosed within 30 months of a negative screening result and before the next recommended examination. Gender, age, stage, and site distribution of interval cancers were compared with those in the screen-detected group. Results. Within the study period, 97 tumors were screen-detected and 74 tumors were diagnosed after a negative screening. In addition, 17 CRC (18.3%) were found after an inconclusive result and 2 cases were diagnosed within the surveillance interval (2.1%). There was an increase of interval cancers over the four rounds (from 32.4% to 46.0%). When compared with screen-detected cancers, interval cancers were found predominantly in the rectum (OR: 3.66; 95% CI: 1.51–8.88) and at more advanced stages (P=0.025). Conclusion. There are large numbers of cancer that are not detected through fecal occult blood test-based screening. The low sensitivity should be emphasized to ensure that individuals with symptoms are not falsely reassured.http://dx.doi.org/10.1155/2015/672410 |
| spellingShingle | M. Garcia X. Domènech C. Vidal E. Torné N. Milà G. Binefa L. Benito V. Moreno Interval Cancers in a Population-Based Screening Program for Colorectal Cancer in Catalonia, Spain Gastroenterology Research and Practice |
| title | Interval Cancers in a Population-Based Screening Program for Colorectal Cancer in Catalonia, Spain |
| title_full | Interval Cancers in a Population-Based Screening Program for Colorectal Cancer in Catalonia, Spain |
| title_fullStr | Interval Cancers in a Population-Based Screening Program for Colorectal Cancer in Catalonia, Spain |
| title_full_unstemmed | Interval Cancers in a Population-Based Screening Program for Colorectal Cancer in Catalonia, Spain |
| title_short | Interval Cancers in a Population-Based Screening Program for Colorectal Cancer in Catalonia, Spain |
| title_sort | interval cancers in a population based screening program for colorectal cancer in catalonia spain |
| url | http://dx.doi.org/10.1155/2015/672410 |
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