Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome
Introduction Cholecystokinin (CCK) is involved in several metabolic pathways, and CCK agonists are considered as a potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS). As genetic variability of cholecystokinin A and B receptor gen...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2022-06-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/Genetic-variability-in-the-cholecystokinin-A-receptor-affects-lipid-profile-and-glucose,150867,0,2.html |
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| author | Eva Drnovsek Mojca Jensterle Katja Goričar Sara Redenšek Andrej Janež Irina Milisav Vita Dolžan |
| author_facet | Eva Drnovsek Mojca Jensterle Katja Goričar Sara Redenšek Andrej Janež Irina Milisav Vita Dolžan |
| author_sort | Eva Drnovsek |
| collection | DOAJ |
| description | Introduction
Cholecystokinin (CCK) is involved in several metabolic pathways, and CCK agonists are considered as a potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS). As genetic variability of cholecystokinin A and B receptor genes (CCKAR and CCKBR, respectively) may modify their biological actions, we investigated the impact of CCKAR and CCKBR genetic variability on anthropometric and metabolic parameters in patients with PCOS.
Material and methods
Our cross-sectional study included 168 patients with PCOS and 82 healthy female controls genotyped for polymorphisms in CCKAR (rs6448456 and rs1800857) and CCKBR (rs2929180, rs1800843, rs1042047 and rs1042048) genes.
Results
The investigated polymorphisms were not associated with anthropometric characteristics of patients with PCOS. However, among healthy controls, carriers of at least one polymorphic CCKBR rs1800843 allele had a larger waist circumference (p = 0.027) and more visceral fat (p = 0.046). Among PCOS patients, carriers of at least one polymorphic CCKAR rs6448456 C allele had significantly higher total blood cholesterol and LDL, and significantly lower blood glucose levels after 30, 60 and 90 minutes of the oral glucose tolerance test (all p < 0.05). Healthy controls with at least one polymorphic CCKAR rs1800857 C allele were less likely to have a high metabolic syndrome burden (p = 0.029).
Conclusions
Genetic variability in CCKAR affects lipid profile and post-load glucose levels in patients with PCOS and is associated with metabolic syndrome burden in healthy young women. Further investigation of the role of genetic variability in CCKAR and CCKBR could contribute to development of individually tailored treatment strategies with CCK receptor agonists. |
| format | Article |
| id | doaj-art-d8dc779e737848d3aa2994bf155de40c |
| institution | Kabale University |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj-art-d8dc779e737848d3aa2994bf155de40c2025-01-27T10:45:12ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512022-06-012061993200110.5114/aoms/150867150867Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndromeEva Drnovsek0Mojca Jensterle1Katja Goričar2Sara Redenšek3https://orcid.org/0000-0003-4876-6534Andrej Janež4Irina Milisav5Vita Dolžan6Faculty of Medicine, University of Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, SloveniaPharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, SloveniaPharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, SloveniaInstitute of Pathophysiology, Faculty of Medicine, University of Ljubljana, SloveniaPharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, SloveniaIntroduction Cholecystokinin (CCK) is involved in several metabolic pathways, and CCK agonists are considered as a potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS). As genetic variability of cholecystokinin A and B receptor genes (CCKAR and CCKBR, respectively) may modify their biological actions, we investigated the impact of CCKAR and CCKBR genetic variability on anthropometric and metabolic parameters in patients with PCOS. Material and methods Our cross-sectional study included 168 patients with PCOS and 82 healthy female controls genotyped for polymorphisms in CCKAR (rs6448456 and rs1800857) and CCKBR (rs2929180, rs1800843, rs1042047 and rs1042048) genes. Results The investigated polymorphisms were not associated with anthropometric characteristics of patients with PCOS. However, among healthy controls, carriers of at least one polymorphic CCKBR rs1800843 allele had a larger waist circumference (p = 0.027) and more visceral fat (p = 0.046). Among PCOS patients, carriers of at least one polymorphic CCKAR rs6448456 C allele had significantly higher total blood cholesterol and LDL, and significantly lower blood glucose levels after 30, 60 and 90 minutes of the oral glucose tolerance test (all p < 0.05). Healthy controls with at least one polymorphic CCKAR rs1800857 C allele were less likely to have a high metabolic syndrome burden (p = 0.029). Conclusions Genetic variability in CCKAR affects lipid profile and post-load glucose levels in patients with PCOS and is associated with metabolic syndrome burden in healthy young women. Further investigation of the role of genetic variability in CCKAR and CCKBR could contribute to development of individually tailored treatment strategies with CCK receptor agonists.https://www.archivesofmedicalscience.com/Genetic-variability-in-the-cholecystokinin-A-receptor-affects-lipid-profile-and-glucose,150867,0,2.htmlcholecystokinincckarcckbrpcospolymorphism |
| spellingShingle | Eva Drnovsek Mojca Jensterle Katja Goričar Sara Redenšek Andrej Janež Irina Milisav Vita Dolžan Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome Archives of Medical Science cholecystokinin cckar cckbr pcos polymorphism |
| title | Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome |
| title_full | Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome |
| title_fullStr | Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome |
| title_full_unstemmed | Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome |
| title_short | Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome |
| title_sort | genetic variability in the cholecystokinin a receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome |
| topic | cholecystokinin cckar cckbr pcos polymorphism |
| url | https://www.archivesofmedicalscience.com/Genetic-variability-in-the-cholecystokinin-A-receptor-affects-lipid-profile-and-glucose,150867,0,2.html |
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