Pore formation by the CDTb component of the Clostridioides difficile binary toxin is Ca2+-dependent

Pore formation by the CDTb component of the Clostridioides difficile binary toxin is Ca2+-dependent

Abstract Clostridioides difficile infection (CDI) is one of the five most urgent bacterial threats in the United States. Furthermore, hypervirulent CDI strains express a third toxin termed the C. difficile binary toxin (CDT), and its molecular mechanism for entering host cells is not fully elucidate...

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Main Authors: Dinendra L. Abeyawardhane, Spiridon E. Sevdalis, Kaylin A. Adipietro, Raquel Godoy-Ruiz, Kristen M. Varney, Izza F. Nawaz, Alejandro X. Spittel, Daniel Hunter, Richard R. Rustandi, Vitalii I. Silin, Amedee des Georges, Mary E. Cook, Edwin Pozharski, David J. Weber
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08343-x
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