Unmasking the Area Postrema on MRI: Utility of 3D FLAIR, 3D-T2, and 3D-DIR Sequences in a Case–Control Study
The area postrema (AP) is a key circumventricular organ involved in the regulation of autonomic functions. Accurate identification of the AP via MRI is essential in neuroimaging but it is challenging. This study evaluated 3D FSE Cube T2WI, 3D FSE Cube FLAIR, and 3D DIR sequences to improve AP detect...
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2025-01-01
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| author | Javier Lara-García Jessica Romo-Martínez Jonathan Javier De-La-Cruz-Cisneros Marco Antonio Olvera-Olvera Luis Jesús Márquez-Bejarano |
| author_facet | Javier Lara-García Jessica Romo-Martínez Jonathan Javier De-La-Cruz-Cisneros Marco Antonio Olvera-Olvera Luis Jesús Márquez-Bejarano |
| author_sort | Javier Lara-García |
| collection | DOAJ |
| description | The area postrema (AP) is a key circumventricular organ involved in the regulation of autonomic functions. Accurate identification of the AP via MRI is essential in neuroimaging but it is challenging. This study evaluated 3D FSE Cube T2WI, 3D FSE Cube FLAIR, and 3D DIR sequences to improve AP detection in patients with and without multiple sclerosis (MS). A case–control study included 35 patients with MS and 35 with other non-demyelinating central nervous system diseases (ND-CNSD). MRI images were acquired employing 3D DIR, 3D FSE Cube FLAIR, and 3D FSE Cube T2WI sequences. The evaluation of AP was conducted using a 3-point scale. Statistical analysis was performed with the chi-square test used to assess group homogeneity and differences between sequences. No significant differences were found in the visualization of the AP between the MS and ND-CNSD groups across the sequences or planes. The AP was not visible in 27.6% of the 3D FSE Cube T2WI sequences, while it was visualized in 99% of the 3D FSE Cube FLAIR sequences and 100% of the 3D DIR sequences. The 3D DIR sequence showed superior performance in identifying the AP. |
| format | Article |
| id | doaj-art-d8d5751a086f4002a0c0a0f5cefcda5f |
| institution | Kabale University |
| issn | 2313-433X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Imaging |
| spelling | doaj-art-d8d5751a086f4002a0c0a0f5cefcda5f2025-01-24T13:36:17ZengMDPI AGJournal of Imaging2313-433X2025-01-011111610.3390/jimaging11010016Unmasking the Area Postrema on MRI: Utility of 3D FLAIR, 3D-T2, and 3D-DIR Sequences in a Case–Control StudyJavier Lara-García0Jessica Romo-Martínez1Jonathan Javier De-La-Cruz-Cisneros2Marco Antonio Olvera-Olvera3Luis Jesús Márquez-Bejarano4Department of Radiology, Hospital de Especialidades del Centro Médico Nacional de Occidente, Mexican Social Security Institute IMSS, Guadalajara 44340, MexicoDepartment of Radiology, Hospital de Especialidades del Centro Médico Nacional de Occidente, Mexican Social Security Institute IMSS, Guadalajara 44340, MexicoDepartment of Radiology, Hospital de Especialidades del Centro Médico Nacional de Occidente, Mexican Social Security Institute IMSS, Guadalajara 44340, MexicoHospital General de Zona No.21, Mexican Social Security Institute IMSS, León 37380, MexicoDepartment of Physiology, Centro Universitario de Ciencias de la Salud, University of Guadalajara, Guadalajara 44340, MexicoThe area postrema (AP) is a key circumventricular organ involved in the regulation of autonomic functions. Accurate identification of the AP via MRI is essential in neuroimaging but it is challenging. This study evaluated 3D FSE Cube T2WI, 3D FSE Cube FLAIR, and 3D DIR sequences to improve AP detection in patients with and without multiple sclerosis (MS). A case–control study included 35 patients with MS and 35 with other non-demyelinating central nervous system diseases (ND-CNSD). MRI images were acquired employing 3D DIR, 3D FSE Cube FLAIR, and 3D FSE Cube T2WI sequences. The evaluation of AP was conducted using a 3-point scale. Statistical analysis was performed with the chi-square test used to assess group homogeneity and differences between sequences. No significant differences were found in the visualization of the AP between the MS and ND-CNSD groups across the sequences or planes. The AP was not visible in 27.6% of the 3D FSE Cube T2WI sequences, while it was visualized in 99% of the 3D FSE Cube FLAIR sequences and 100% of the 3D DIR sequences. The 3D DIR sequence showed superior performance in identifying the AP.https://www.mdpi.com/2313-433X/11/1/16area postremaMRIdemyelinating diseasesmultiple sclerosisdouble inversion recovery |
| spellingShingle | Javier Lara-García Jessica Romo-Martínez Jonathan Javier De-La-Cruz-Cisneros Marco Antonio Olvera-Olvera Luis Jesús Márquez-Bejarano Unmasking the Area Postrema on MRI: Utility of 3D FLAIR, 3D-T2, and 3D-DIR Sequences in a Case–Control Study Journal of Imaging area postrema MRI demyelinating diseases multiple sclerosis double inversion recovery |
| title | Unmasking the Area Postrema on MRI: Utility of 3D FLAIR, 3D-T2, and 3D-DIR Sequences in a Case–Control Study |
| title_full | Unmasking the Area Postrema on MRI: Utility of 3D FLAIR, 3D-T2, and 3D-DIR Sequences in a Case–Control Study |
| title_fullStr | Unmasking the Area Postrema on MRI: Utility of 3D FLAIR, 3D-T2, and 3D-DIR Sequences in a Case–Control Study |
| title_full_unstemmed | Unmasking the Area Postrema on MRI: Utility of 3D FLAIR, 3D-T2, and 3D-DIR Sequences in a Case–Control Study |
| title_short | Unmasking the Area Postrema on MRI: Utility of 3D FLAIR, 3D-T2, and 3D-DIR Sequences in a Case–Control Study |
| title_sort | unmasking the area postrema on mri utility of 3d flair 3d t2 and 3d dir sequences in a case control study |
| topic | area postrema MRI demyelinating diseases multiple sclerosis double inversion recovery |
| url | https://www.mdpi.com/2313-433X/11/1/16 |
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