Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats
Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO4) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO4 in rats. ZnY or ZnSO4 were orally administered to rats at a single dose of 4...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/217142 |
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| author | Shuangqing Zhang Yan Zhang Ning Peng Haibo Zhang Juan Yao Zhihong Li Liegang Liu |
| author_facet | Shuangqing Zhang Yan Zhang Ning Peng Haibo Zhang Juan Yao Zhihong Li Liegang Liu |
| author_sort | Shuangqing Zhang |
| collection | DOAJ |
| description | Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO4) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO4 in rats. ZnY or ZnSO4 were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry. Maximum plasma concentration values were 3.87 and 2.81 μg/mL for ZnY and ZnSO4, respectively. Both ZnY and ZnSO4 were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues. Compared to ZnSO4, the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO4. |
| format | Article |
| id | doaj-art-d8d49798f88e4c8cb4bd2aa64e2f275c |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d8d49798f88e4c8cb4bd2aa64e2f275c2025-02-03T01:20:43ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/217142217142Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in RatsShuangqing Zhang0Yan Zhang1Ning Peng2Haibo Zhang3Juan Yao4Zhihong Li5Liegang Liu6Division of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, ChinaDivision of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, ChinaDivision of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, ChinaDivision of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, ChinaDivision of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, ChinaDivision of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, ChinaDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaZinc-enriched yeast (ZnY) and zinc sulfate (ZnSO4) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO4 in rats. ZnY or ZnSO4 were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry. Maximum plasma concentration values were 3.87 and 2.81 μg/mL for ZnY and ZnSO4, respectively. Both ZnY and ZnSO4 were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues. Compared to ZnSO4, the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO4.http://dx.doi.org/10.1155/2014/217142 |
| spellingShingle | Shuangqing Zhang Yan Zhang Ning Peng Haibo Zhang Juan Yao Zhihong Li Liegang Liu Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats The Scientific World Journal |
| title | Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats |
| title_full | Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats |
| title_fullStr | Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats |
| title_full_unstemmed | Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats |
| title_short | Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats |
| title_sort | pharmacokinetics and biodistribution of zinc enriched yeast in rats |
| url | http://dx.doi.org/10.1155/2014/217142 |
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