Poor Reporting of Outcomes Beyond Accuracy in Point-of-Care Tests for Syphilis: A Call for a Framework
Background. Point-of-care (POC) diagnostics for syphilis can contribute to epidemic control by offering a timely knowledge of serostatus. Although accuracy data on POC syphilis tests have been widely published, few studies have evaluated broader outcomes beyond accuracy that impact patients and heal...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2014/465932 |
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| _version_ | 1832554321026220032 |
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| author | Yalda Jafari Mira Johri Lawrence Joseph Caroline Vadnais Nitika Pant Pai |
| author_facet | Yalda Jafari Mira Johri Lawrence Joseph Caroline Vadnais Nitika Pant Pai |
| author_sort | Yalda Jafari |
| collection | DOAJ |
| description | Background. Point-of-care (POC) diagnostics for syphilis can contribute to epidemic control by offering a timely knowledge of serostatus. Although accuracy data on POC syphilis tests have been widely published, few studies have evaluated broader outcomes beyond accuracy that impact patients and health systems. We comprehensively reviewed evidence and reporting of these implementation research outcomes (IROs), and proposed a framework to improve their quality. Methods. Three reviewers systematically searched 6 electronic databases from 1980 to 2014 for syphilis POC studies reporting IROs. Data were abstracted and findings synthesised narratively. Results. Of 71 studies identified, 38 documented IROs. IROs were subclassified into preference (7), acceptability (15), feasibility (15), barriers and challenges (15), impact (13), and prevalence (23). Using our framework and definitions, a pattern of incomplete documentation, inconsistent definitions, and lack of clarity was identified across all IROs. Conclusion. Although POC screening tests for syphilis were generally favourably evaluated across a range of outcomes, the quality of evidence was compromised by inconsistent definitions, poor methodology, and documentation of outcomes. A framework for standardized reporting of outcomes beyond accuracy was proposed and considered a necessary first step towards an effective implementation of these metrics in POC diagnostics research. |
| format | Article |
| id | doaj-art-d8bcbe3d77a248dbbe526572ec442751 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-d8bcbe3d77a248dbbe526572ec4427512025-02-03T05:51:57ZengWileyAIDS Research and Treatment2090-12402090-12592014-01-01201410.1155/2014/465932465932Poor Reporting of Outcomes Beyond Accuracy in Point-of-Care Tests for Syphilis: A Call for a FrameworkYalda Jafari0Mira Johri1Lawrence Joseph2Caroline Vadnais3Nitika Pant Pai4Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, QC, H3A 1A2, CanadaDepartment of Health Administration, Université de Montréal, Montreal, QC, H3C 3J7, CanadaDepartment of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, QC, H3A 1A2, CanadaDivision of Clinical Epidemiology, Department of Medicine, Royal Victoria Hospital, McGill University Health Centre, V Building (V2.19), 687 Pine Avenue West, Montreal, QC, H3A 1A1, CanadaDivision of Clinical Epidemiology, Department of Medicine, Royal Victoria Hospital, McGill University Health Centre, V Building (V2.19), 687 Pine Avenue West, Montreal, QC, H3A 1A1, CanadaBackground. Point-of-care (POC) diagnostics for syphilis can contribute to epidemic control by offering a timely knowledge of serostatus. Although accuracy data on POC syphilis tests have been widely published, few studies have evaluated broader outcomes beyond accuracy that impact patients and health systems. We comprehensively reviewed evidence and reporting of these implementation research outcomes (IROs), and proposed a framework to improve their quality. Methods. Three reviewers systematically searched 6 electronic databases from 1980 to 2014 for syphilis POC studies reporting IROs. Data were abstracted and findings synthesised narratively. Results. Of 71 studies identified, 38 documented IROs. IROs were subclassified into preference (7), acceptability (15), feasibility (15), barriers and challenges (15), impact (13), and prevalence (23). Using our framework and definitions, a pattern of incomplete documentation, inconsistent definitions, and lack of clarity was identified across all IROs. Conclusion. Although POC screening tests for syphilis were generally favourably evaluated across a range of outcomes, the quality of evidence was compromised by inconsistent definitions, poor methodology, and documentation of outcomes. A framework for standardized reporting of outcomes beyond accuracy was proposed and considered a necessary first step towards an effective implementation of these metrics in POC diagnostics research.http://dx.doi.org/10.1155/2014/465932 |
| spellingShingle | Yalda Jafari Mira Johri Lawrence Joseph Caroline Vadnais Nitika Pant Pai Poor Reporting of Outcomes Beyond Accuracy in Point-of-Care Tests for Syphilis: A Call for a Framework AIDS Research and Treatment |
| title | Poor Reporting of Outcomes Beyond Accuracy in Point-of-Care Tests for Syphilis: A Call for a Framework |
| title_full | Poor Reporting of Outcomes Beyond Accuracy in Point-of-Care Tests for Syphilis: A Call for a Framework |
| title_fullStr | Poor Reporting of Outcomes Beyond Accuracy in Point-of-Care Tests for Syphilis: A Call for a Framework |
| title_full_unstemmed | Poor Reporting of Outcomes Beyond Accuracy in Point-of-Care Tests for Syphilis: A Call for a Framework |
| title_short | Poor Reporting of Outcomes Beyond Accuracy in Point-of-Care Tests for Syphilis: A Call for a Framework |
| title_sort | poor reporting of outcomes beyond accuracy in point of care tests for syphilis a call for a framework |
| url | http://dx.doi.org/10.1155/2014/465932 |
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