Lipid Levels and Lung Cancer Risk: Findings from the Taiwan National Data Systems from 2012 to 2018
Abstract Background Lipids are known to be involved in carcinogenesis, but the associations between lipid profiles and different lung cancer histological classifications remain unknown. Methods Individuals who participated in national adult health surveillance from 2012 to 2018 were included. For pa...
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| Format: | Article |
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Springer
2025-01-01
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| Series: | Journal of Epidemiology and Global Health |
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| Online Access: | https://doi.org/10.1007/s44197-025-00351-8 |
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| author | Jung-Yueh Chen Nai-Hui Chi Ho-Shen Lee Chia-Ni Hsiung Chang-Wei Wu Kang-Chi Fan Meng-Rui Lee Jann-Yuan Wang Chao-Chi Ho Jin-Yuan Shih |
| author_facet | Jung-Yueh Chen Nai-Hui Chi Ho-Shen Lee Chia-Ni Hsiung Chang-Wei Wu Kang-Chi Fan Meng-Rui Lee Jann-Yuan Wang Chao-Chi Ho Jin-Yuan Shih |
| author_sort | Jung-Yueh Chen |
| collection | DOAJ |
| description | Abstract Background Lipids are known to be involved in carcinogenesis, but the associations between lipid profiles and different lung cancer histological classifications remain unknown. Methods Individuals who participated in national adult health surveillance from 2012 to 2018 were included. For patients who developed lung cancer during follow-up, a 1:2 control group of nonlung cancer participants was selected after matching. Multivariate conditional logistic regression was used to explore the associations between lipid profiles, different lung cancer histological classifications and epidermal growth factor receptor mutation statuses. Subgroup, sensitivity, and dose‒response analyses were also performed. Results A total of 4,704,853 participants (30,337 lung cancer participants and 4,674,516 nonlung cancer participants) were included. In both the main and sensitivity analyses, the associations remained constant between lower high-density lipoprotein (HDL) cholesterol levels and a higher risk of lung cancer (main analysis: odds ratio: 1.13 [1.08–1.18]) and squamous cell carcinoma (1.29 [1.16–1.43]). Hypertriglyceridemia was associated with a lower risk of adenocarcinoma (0.90 [0.84–0.96]) and a higher risk of small cell lung cancer (1.31 [1.11–1.55]). Hypercholesterolemia was associated with a lower risk of squamous cell carcinoma (0.84 [0.76–0.94]). In the subgroup analysis, lower HDL cholesterol levels were associated with greater risk across most subgroups. HDL cholesterol levels also demonstrated a dose‒response association with the development of lung cancer. Conclusions The distinct associations between specific lipid profiles and lung cancer subtypes suggest that lipid metabolism may play different mechanistic roles in lung cancer development. |
| format | Article |
| id | doaj-art-d8bc872bcc4e4e4f930e163945d314cc |
| institution | Kabale University |
| issn | 2210-6014 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Epidemiology and Global Health |
| spelling | doaj-art-d8bc872bcc4e4e4f930e163945d314cc2025-02-02T12:06:55ZengSpringerJournal of Epidemiology and Global Health2210-60142025-01-0115111210.1007/s44197-025-00351-8Lipid Levels and Lung Cancer Risk: Findings from the Taiwan National Data Systems from 2012 to 2018Jung-Yueh Chen0Nai-Hui Chi1Ho-Shen Lee2Chia-Ni Hsiung3Chang-Wei Wu4Kang-Chi Fan5Meng-Rui Lee6Jann-Yuan Wang7Chao-Chi Ho8Jin-Yuan Shih9School of Medicine, College of Medicine, I-Shou UniversityDepartment of Nursing, National Taiwan University HospitalDepartment of Internal Medicine, E-DA Hospital, I-Shou UniversityProgram in Precision Medicine, National Tsing Hua UniversityDepartment of Internal Medicine, National Taiwan University Hospital Hsinchu BranchDepartment of Internal Medicine, National Taiwan University Hospital Hsinchu BranchDepartment of Internal Medicine, National Taiwan University Hospital Hsinchu BranchDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan UniversityDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan UniversityDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan UniversityAbstract Background Lipids are known to be involved in carcinogenesis, but the associations between lipid profiles and different lung cancer histological classifications remain unknown. Methods Individuals who participated in national adult health surveillance from 2012 to 2018 were included. For patients who developed lung cancer during follow-up, a 1:2 control group of nonlung cancer participants was selected after matching. Multivariate conditional logistic regression was used to explore the associations between lipid profiles, different lung cancer histological classifications and epidermal growth factor receptor mutation statuses. Subgroup, sensitivity, and dose‒response analyses were also performed. Results A total of 4,704,853 participants (30,337 lung cancer participants and 4,674,516 nonlung cancer participants) were included. In both the main and sensitivity analyses, the associations remained constant between lower high-density lipoprotein (HDL) cholesterol levels and a higher risk of lung cancer (main analysis: odds ratio: 1.13 [1.08–1.18]) and squamous cell carcinoma (1.29 [1.16–1.43]). Hypertriglyceridemia was associated with a lower risk of adenocarcinoma (0.90 [0.84–0.96]) and a higher risk of small cell lung cancer (1.31 [1.11–1.55]). Hypercholesterolemia was associated with a lower risk of squamous cell carcinoma (0.84 [0.76–0.94]). In the subgroup analysis, lower HDL cholesterol levels were associated with greater risk across most subgroups. HDL cholesterol levels also demonstrated a dose‒response association with the development of lung cancer. Conclusions The distinct associations between specific lipid profiles and lung cancer subtypes suggest that lipid metabolism may play different mechanistic roles in lung cancer development.https://doi.org/10.1007/s44197-025-00351-8Lung cancerTriglycerideTotal cholesterolHigh-density lipoproteinEGFR-mutated lung cancer |
| spellingShingle | Jung-Yueh Chen Nai-Hui Chi Ho-Shen Lee Chia-Ni Hsiung Chang-Wei Wu Kang-Chi Fan Meng-Rui Lee Jann-Yuan Wang Chao-Chi Ho Jin-Yuan Shih Lipid Levels and Lung Cancer Risk: Findings from the Taiwan National Data Systems from 2012 to 2018 Journal of Epidemiology and Global Health Lung cancer Triglyceride Total cholesterol High-density lipoprotein EGFR-mutated lung cancer |
| title | Lipid Levels and Lung Cancer Risk: Findings from the Taiwan National Data Systems from 2012 to 2018 |
| title_full | Lipid Levels and Lung Cancer Risk: Findings from the Taiwan National Data Systems from 2012 to 2018 |
| title_fullStr | Lipid Levels and Lung Cancer Risk: Findings from the Taiwan National Data Systems from 2012 to 2018 |
| title_full_unstemmed | Lipid Levels and Lung Cancer Risk: Findings from the Taiwan National Data Systems from 2012 to 2018 |
| title_short | Lipid Levels and Lung Cancer Risk: Findings from the Taiwan National Data Systems from 2012 to 2018 |
| title_sort | lipid levels and lung cancer risk findings from the taiwan national data systems from 2012 to 2018 |
| topic | Lung cancer Triglyceride Total cholesterol High-density lipoprotein EGFR-mutated lung cancer |
| url | https://doi.org/10.1007/s44197-025-00351-8 |
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