Immunological criteria for the diagnosis of multisystem inflammatory syndrome associated with MERS-COV-2 and infectious diseases with sepsis in children
Multisystem inflammatory syndrome associated with SARSCoV2 in children is a potentially life–threatening condition that develops several weeks after COVID19 and is characterized by a hyperinflammatory response with damage to ≥2 organs and systems. At the moment, there is no understanding of how t...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2024-12-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/1709 |
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| author | Yu. E. Konstantinovа A. A. Zhirkov L. A. Alekseeva A. A. Vilnits T. V. Bessonov K. V. Zhdanov |
| author_facet | Yu. E. Konstantinovа A. A. Zhirkov L. A. Alekseeva A. A. Vilnits T. V. Bessonov K. V. Zhdanov |
| author_sort | Yu. E. Konstantinovа |
| collection | DOAJ |
| description | Multisystem inflammatory syndrome associated with SARSCoV2 in children is a potentially life–threatening condition that develops several weeks after COVID19 and is characterized by a hyperinflammatory response with damage to ≥2 organs and systems. At the moment, there is no understanding of how the mechanisms of development and course of this disease differ from other more studied similar conditions, for example, sepsis in infectious diseases.The aim is to compare immunological parameters in multisystem inflammatory syndrome associated with SARSCoV2 and infectious diseases with sepsis in children.Materials and methods. The concentration of cytokines, chemokines and growth factors in serum was determined in 14 children with multisystem inflammatory syndrome associated with SARSCoV2, 19 children and 16 healthy children (control group) with IHS.Results. Both common and distinctive signs of inflammation were found in patients with MVSD and IHS. Patients with MVSD, unlike healthy children, were characterized by a decrease in Basic FGF, IFNa2, IL1a, IL1b, IL2, IL3, IL4, IL5, IL9, IL12(p40), IL13, IL18, PDGFBB, RANTES, TRAIL and Boost GCSF, HGF, IL1ra, IL2Ra, IL6, IL10, IL16, IP10, MCP1, MCSF, MIG. Statistically significant in MVSD was a decrease in IL2 and IL5 levels compared with the control group, but significantly less pronounced than in IS (8.0 times and 3.5 times, respectively), a pronounced increase in MIG levels (12.0 times compared with children with IS). The RANTES index (a proinflammatory chemokine that attracts leukocytes to the focus of inflammation) decreased with MVSD, while it increased with IS compared with the control group.Conclusions. Immunological features of MISC have been found that distinguish the pathogenesis of the syndrome from infectious diseases occurring with sepsis. The identified markers can be used as criteria for the differential diagnosis of these diseases. |
| format | Article |
| id | doaj-art-d895deab7c5d46d48f0379299c43e11e |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-d895deab7c5d46d48f0379299c43e11e2025-08-20T03:44:20ZrusJournal InfectologyЖурнал инфектологии2072-67322024-12-01164495910.22625/2072-6732-2024-16-4-49-591184Immunological criteria for the diagnosis of multisystem inflammatory syndrome associated with MERS-COV-2 and infectious diseases with sepsis in childrenYu. E. Konstantinovа0A. A. Zhirkov1L. A. Alekseeva2A. A. Vilnits3T. V. Bessonov4K. V. Zhdanov5Pediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesPediatric Research and Clinical Center for Infectious DiseasesMultisystem inflammatory syndrome associated with SARSCoV2 in children is a potentially life–threatening condition that develops several weeks after COVID19 and is characterized by a hyperinflammatory response with damage to ≥2 organs and systems. At the moment, there is no understanding of how the mechanisms of development and course of this disease differ from other more studied similar conditions, for example, sepsis in infectious diseases.The aim is to compare immunological parameters in multisystem inflammatory syndrome associated with SARSCoV2 and infectious diseases with sepsis in children.Materials and methods. The concentration of cytokines, chemokines and growth factors in serum was determined in 14 children with multisystem inflammatory syndrome associated with SARSCoV2, 19 children and 16 healthy children (control group) with IHS.Results. Both common and distinctive signs of inflammation were found in patients with MVSD and IHS. Patients with MVSD, unlike healthy children, were characterized by a decrease in Basic FGF, IFNa2, IL1a, IL1b, IL2, IL3, IL4, IL5, IL9, IL12(p40), IL13, IL18, PDGFBB, RANTES, TRAIL and Boost GCSF, HGF, IL1ra, IL2Ra, IL6, IL10, IL16, IP10, MCP1, MCSF, MIG. Statistically significant in MVSD was a decrease in IL2 and IL5 levels compared with the control group, but significantly less pronounced than in IS (8.0 times and 3.5 times, respectively), a pronounced increase in MIG levels (12.0 times compared with children with IS). The RANTES index (a proinflammatory chemokine that attracts leukocytes to the focus of inflammation) decreased with MVSD, while it increased with IS compared with the control group.Conclusions. Immunological features of MISC have been found that distinguish the pathogenesis of the syndrome from infectious diseases occurring with sepsis. The identified markers can be used as criteria for the differential diagnosis of these diseases.https://journal.niidi.ru/jofin/article/view/1709childrencytokineschemokinesgrowth factorsimmunologymultisystem inflammatory syndromesarscov2sepsis |
| spellingShingle | Yu. E. Konstantinovа A. A. Zhirkov L. A. Alekseeva A. A. Vilnits T. V. Bessonov K. V. Zhdanov Immunological criteria for the diagnosis of multisystem inflammatory syndrome associated with MERS-COV-2 and infectious diseases with sepsis in children Журнал инфектологии children cytokines chemokines growth factors immunology multisystem inflammatory syndrome sarscov2 sepsis |
| title | Immunological criteria for the diagnosis of multisystem inflammatory syndrome associated with MERS-COV-2 and infectious diseases with sepsis in children |
| title_full | Immunological criteria for the diagnosis of multisystem inflammatory syndrome associated with MERS-COV-2 and infectious diseases with sepsis in children |
| title_fullStr | Immunological criteria for the diagnosis of multisystem inflammatory syndrome associated with MERS-COV-2 and infectious diseases with sepsis in children |
| title_full_unstemmed | Immunological criteria for the diagnosis of multisystem inflammatory syndrome associated with MERS-COV-2 and infectious diseases with sepsis in children |
| title_short | Immunological criteria for the diagnosis of multisystem inflammatory syndrome associated with MERS-COV-2 and infectious diseases with sepsis in children |
| title_sort | immunological criteria for the diagnosis of multisystem inflammatory syndrome associated with mers cov 2 and infectious diseases with sepsis in children |
| topic | children cytokines chemokines growth factors immunology multisystem inflammatory syndrome sarscov2 sepsis |
| url | https://journal.niidi.ru/jofin/article/view/1709 |
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