Shouhui Tongbian Capsule ameliorates 5-fluorouracil induced constipation in mice by modulating gut microbiota and activating PI3K/AKT/AQP3 signaling pathway

Shouhui Tongbian Capsule ameliorates 5-fluorouracil induced constipation in mice by modulating gut microbiota and activating PI3K/AKT/AQP3 signaling pathway

ObjectiveShouhui Tongbian Capsule (SHTC) has been clinically applied to treat various types of constipation, including chemotherapy-induced constipation. However, the pharmacological mechanism by which it regulates intestinal peristalsis and treats constipation is unclear. In this study, we aimed to...

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Bibliographic Details
Main Authors: Yawei Zhang, Yang Dong, Chenghong Sun, Lufan Zhang, Yi Zhang, Dan Wang, Qian Chen, Jingchun Yao, Yuzheng Wu, Tao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Microbiology
Subjects:
Shouhui Tongbian Capsule (SHTC)
5-fluorouracil (5-FU)
chemotherapy-induced constipation (CIC)
gut microbiota
fecal microbiota transplantation (FMT)
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1596881/full
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