Sleep quality among sample of Egyptian patients with Alzheimer’s disease: risk factors and role of genetic profiling for ACE, ACE 2 and APO E genotypes
Abstract Background Most individuals having Alzheimer’s disease generally experience increased frequency of awakenings as well as prolonged wakefulness periods at night. Brain wave research indicate reductions in both REM (dreaming stage) along with NREM (non-dreaming stage). The inherited pattern o...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
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| Online Access: | https://doi.org/10.1186/s41983-024-00928-3 |
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| author | Khaled Ahmed Elbeh Mohamed Abdala Abbas Mohammed H. Hassan Mohamed Moslem Hefny Shimaa Fathy Sakr Reham Bakry Mohamed Mahmoud Ahmed Bekiet Tarek Desoky |
| author_facet | Khaled Ahmed Elbeh Mohamed Abdala Abbas Mohammed H. Hassan Mohamed Moslem Hefny Shimaa Fathy Sakr Reham Bakry Mohamed Mahmoud Ahmed Bekiet Tarek Desoky |
| author_sort | Khaled Ahmed Elbeh |
| collection | DOAJ |
| description | Abstract Background Most individuals having Alzheimer’s disease generally experience increased frequency of awakenings as well as prolonged wakefulness periods at night. Brain wave research indicate reductions in both REM (dreaming stage) along with NREM (non-dreaming stage). The inherited pattern of Alzheimer’s disease is attributed to presence of genetic polymorphisms. The association of these polymorphisms and sleep pattern in Alzheimer’s disease patients was not assessed before. Purpose This research was aimed at assessing the association between sleep quality as well as genetic polymorphisms of ACE, ACE2 and Apo E among Alzheimer’s disease patients in Upper Egypt. Patients and methods Our cross-sectional study with analytic component involved 50 cases having Alzheimer’s disease evaluated utilizing Pittsburg sleep quality index for sleep quality. They were accordingly divided into good as well as poor sleep quality groups. Genetic analysis of ACE, ACE2 (rs2285666) SNPs and Apo E (rs121918398) SNPs was done using (RFLP-PCR) I. Results No statistically significant variation was documented among both groups regarding age as well as age at diagnosis. Female patients were more susceptible for poor sleep quality. In addition, patients came from rural areas were significantly higher among poor sleep quality group. Statistical significant variations were documented among both groups as regard presenting symptoms and HAM-A and HAM-D. No statistically significant variations were documented among both groups as regard ACE genotypes; however, ACE 2 AA genotype and A allele were higher with statistically significant difference among poor sleep quality group. Apo E3/E4 genotype and E4 allele were greater with statistically significant variations among poor sleep quality group. Conclusions Female patient and rural Alzheimer’s disease patients at high risk for poor sleep quality. In addition, Apo E4 carriers and ACE2 AA carriers are at increasing susceptibility for poor sleep quality. |
| format | Article |
| id | doaj-art-d88d75e3262e4fde8eff86dddcad81db |
| institution | Kabale University |
| issn | 1687-8329 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj-art-d88d75e3262e4fde8eff86dddcad81db2025-01-26T12:20:57ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292025-01-016111710.1186/s41983-024-00928-3Sleep quality among sample of Egyptian patients with Alzheimer’s disease: risk factors and role of genetic profiling for ACE, ACE 2 and APO E genotypesKhaled Ahmed Elbeh0Mohamed Abdala Abbas1Mohammed H. Hassan2Mohamed Moslem Hefny3Shimaa Fathy Sakr4Reham Bakry Mohamed5Mahmoud Ahmed Bekiet6Tarek Desoky7Psychiatric Department, Faculty of Medicine, Assuit UniversityDepartment of Neurology, Luxor Faculty of Medicine-Luxor UniversityMedical Biochemistry, Faculty of Medicine, South Valley UniversityPsychiatry Department, Faculty of Medicine, South Valley UniversityMolecular Biology Unit, Medical Technology Center, Medical Research InstituteDepartment of Neurology, Luxor Faculty of Medicine-Luxor UniversityPsychiatry Department, Faculty of Medicine, South Valley UniversityPsychiatry Department, Faculty of Medicine, South Valley UniversityAbstract Background Most individuals having Alzheimer’s disease generally experience increased frequency of awakenings as well as prolonged wakefulness periods at night. Brain wave research indicate reductions in both REM (dreaming stage) along with NREM (non-dreaming stage). The inherited pattern of Alzheimer’s disease is attributed to presence of genetic polymorphisms. The association of these polymorphisms and sleep pattern in Alzheimer’s disease patients was not assessed before. Purpose This research was aimed at assessing the association between sleep quality as well as genetic polymorphisms of ACE, ACE2 and Apo E among Alzheimer’s disease patients in Upper Egypt. Patients and methods Our cross-sectional study with analytic component involved 50 cases having Alzheimer’s disease evaluated utilizing Pittsburg sleep quality index for sleep quality. They were accordingly divided into good as well as poor sleep quality groups. Genetic analysis of ACE, ACE2 (rs2285666) SNPs and Apo E (rs121918398) SNPs was done using (RFLP-PCR) I. Results No statistically significant variation was documented among both groups regarding age as well as age at diagnosis. Female patients were more susceptible for poor sleep quality. In addition, patients came from rural areas were significantly higher among poor sleep quality group. Statistical significant variations were documented among both groups as regard presenting symptoms and HAM-A and HAM-D. No statistically significant variations were documented among both groups as regard ACE genotypes; however, ACE 2 AA genotype and A allele were higher with statistically significant difference among poor sleep quality group. Apo E3/E4 genotype and E4 allele were greater with statistically significant variations among poor sleep quality group. Conclusions Female patient and rural Alzheimer’s disease patients at high risk for poor sleep quality. In addition, Apo E4 carriers and ACE2 AA carriers are at increasing susceptibility for poor sleep quality.https://doi.org/10.1186/s41983-024-00928-3Sleep qualityAlzheimer’s diseaseAngiotensin converting enzymesApolipoprotein |
| spellingShingle | Khaled Ahmed Elbeh Mohamed Abdala Abbas Mohammed H. Hassan Mohamed Moslem Hefny Shimaa Fathy Sakr Reham Bakry Mohamed Mahmoud Ahmed Bekiet Tarek Desoky Sleep quality among sample of Egyptian patients with Alzheimer’s disease: risk factors and role of genetic profiling for ACE, ACE 2 and APO E genotypes The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Sleep quality Alzheimer’s disease Angiotensin converting enzymes Apolipoprotein |
| title | Sleep quality among sample of Egyptian patients with Alzheimer’s disease: risk factors and role of genetic profiling for ACE, ACE 2 and APO E genotypes |
| title_full | Sleep quality among sample of Egyptian patients with Alzheimer’s disease: risk factors and role of genetic profiling for ACE, ACE 2 and APO E genotypes |
| title_fullStr | Sleep quality among sample of Egyptian patients with Alzheimer’s disease: risk factors and role of genetic profiling for ACE, ACE 2 and APO E genotypes |
| title_full_unstemmed | Sleep quality among sample of Egyptian patients with Alzheimer’s disease: risk factors and role of genetic profiling for ACE, ACE 2 and APO E genotypes |
| title_short | Sleep quality among sample of Egyptian patients with Alzheimer’s disease: risk factors and role of genetic profiling for ACE, ACE 2 and APO E genotypes |
| title_sort | sleep quality among sample of egyptian patients with alzheimer s disease risk factors and role of genetic profiling for ace ace 2 and apo e genotypes |
| topic | Sleep quality Alzheimer’s disease Angiotensin converting enzymes Apolipoprotein |
| url | https://doi.org/10.1186/s41983-024-00928-3 |
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