The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis

The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis

Abstract The essential trace element, zinc, regulates virtually all aspects of cellular physiology, particularly cell proliferation and survival. Diverse families of metal transporters, metallothioneins, and metal‐responsive transcriptional regulators are linked to zinc homeostasis. However, the mec...

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Main Authors: Shumin Sun, Enjun Xie, Shan Xu, Suyu Ji, Shufen Wang, Jie Shen, Rong Wang, Xinyi Shen, Yunxing Su, Zijun Song, Xiaotian Wu, Jiahui Zhou, Zhaoxian Cai, Xiaopeng Li, Yan Zhang, Junxia Min, Fudi Wang
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
intestinal barrier integrity
ion selectivity
SLC30A1 structure
zinc homeostasis
Online Access:https://doi.org/10.1002/advs.202406421
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