Prospective evaluation of CYP19A1-mediated aromatase inhibitors for ER+ breast cancers by ultra-high performance liquid chromatography tandem mass spectrometry supported by in silico methods

Human aromatase (CYP19A1) is a membrane-associated microsomal cytochrome P450 enzyme that is responsible for facilitating the conversion of androgens into estrogens. Aromatase inhibitors (AIs) are widely utilized in the management of breast cancer, and the CYP19A1 aromatase is acknowledged as a vali...

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Bibliographic Details
Main Authors: N.J. Gumede, K. Bisetty, L. Escuder-Gilabert, M.J. Medina-Hernandez, S. Sagrado
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Results in Chemistry
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625003388
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