Genetic Variants Related to Increased CKD Progression—A Systematic Review
The incidence and prevalence of chronic kidney disease (CKD) are increasing worldwide. CKD is associated with high morbidity, premature mortality, and high healthcare costs. Genetic variants may influence CKD development and progression. This study aimed to identify the associations between allelic...
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MDPI AG
2025-01-01
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| author | Filipe S. Mira Bárbara Oliveiros Isabel Marques Carreira Rui Alves Ilda Patrícia Ribeiro |
| author_facet | Filipe S. Mira Bárbara Oliveiros Isabel Marques Carreira Rui Alves Ilda Patrícia Ribeiro |
| author_sort | Filipe S. Mira |
| collection | DOAJ |
| description | The incidence and prevalence of chronic kidney disease (CKD) are increasing worldwide. CKD is associated with high morbidity, premature mortality, and high healthcare costs. Genetic variants may influence CKD development and progression. This study aimed to identify the associations between allelic variants and CKD progression. We performed a systematic literature review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The PubMed, Embase, and Cochrane Central databases were used for data collection. Hereditary causes of CKD were excluded from the analysis. A total of 38 reports were included. The selected studies included cohort studies, case-control studies, and genome-wide association studies (GWASs). The studies involved patients of different ethnicities and with comorbid diseases. Several genetic variants were identified in genes that encode proteins related to metabolic processes, oxidative stress, immune regulation, the renin–angiotensin–aldosterone pathway, and epigenetics, among others. These genetic alterations can affect protein function and lead to renal damage, impacting CKD development and progression. Gene polymorphisms can influence CKD progression. Many of these are population-specific, and their relevance may be influenced by the presence of other diseases and environmental factors. Larger studies are needed to confirm the associations described here. |
| format | Article |
| id | doaj-art-d87b728348d147eca6aafa650571790e |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-d87b728348d147eca6aafa650571790e2025-01-24T13:23:30ZengMDPI AGBiology2079-77372025-01-011416810.3390/biology14010068Genetic Variants Related to Increased CKD Progression—A Systematic ReviewFilipe S. Mira0Bárbara Oliveiros1Isabel Marques Carreira2Rui Alves3Ilda Patrícia Ribeiro4Department of Nephrology, Unidade Local de Saúde de Coimbra, 3004-561 Coimbra, PortugalFaculty of Medicine, University of Coimbra, 3004-504 Coimbra, PortugalFaculty of Medicine, University of Coimbra, 3004-504 Coimbra, PortugalDepartment of Nephrology, Unidade Local de Saúde de Coimbra, 3004-561 Coimbra, PortugalFaculty of Medicine, University of Coimbra, 3004-504 Coimbra, PortugalThe incidence and prevalence of chronic kidney disease (CKD) are increasing worldwide. CKD is associated with high morbidity, premature mortality, and high healthcare costs. Genetic variants may influence CKD development and progression. This study aimed to identify the associations between allelic variants and CKD progression. We performed a systematic literature review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The PubMed, Embase, and Cochrane Central databases were used for data collection. Hereditary causes of CKD were excluded from the analysis. A total of 38 reports were included. The selected studies included cohort studies, case-control studies, and genome-wide association studies (GWASs). The studies involved patients of different ethnicities and with comorbid diseases. Several genetic variants were identified in genes that encode proteins related to metabolic processes, oxidative stress, immune regulation, the renin–angiotensin–aldosterone pathway, and epigenetics, among others. These genetic alterations can affect protein function and lead to renal damage, impacting CKD development and progression. Gene polymorphisms can influence CKD progression. Many of these are population-specific, and their relevance may be influenced by the presence of other diseases and environmental factors. Larger studies are needed to confirm the associations described here.https://www.mdpi.com/2079-7737/14/1/68chronic kidney diseaseend-stage renal diseasesingle nucleotide polymorphismestimated glomerular filtration rate (eGFR)geneticsprogression |
| spellingShingle | Filipe S. Mira Bárbara Oliveiros Isabel Marques Carreira Rui Alves Ilda Patrícia Ribeiro Genetic Variants Related to Increased CKD Progression—A Systematic Review Biology chronic kidney disease end-stage renal disease single nucleotide polymorphism estimated glomerular filtration rate (eGFR) genetics progression |
| title | Genetic Variants Related to Increased CKD Progression—A Systematic Review |
| title_full | Genetic Variants Related to Increased CKD Progression—A Systematic Review |
| title_fullStr | Genetic Variants Related to Increased CKD Progression—A Systematic Review |
| title_full_unstemmed | Genetic Variants Related to Increased CKD Progression—A Systematic Review |
| title_short | Genetic Variants Related to Increased CKD Progression—A Systematic Review |
| title_sort | genetic variants related to increased ckd progression a systematic review |
| topic | chronic kidney disease end-stage renal disease single nucleotide polymorphism estimated glomerular filtration rate (eGFR) genetics progression |
| url | https://www.mdpi.com/2079-7737/14/1/68 |
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